Abstract：Objective To investigate the clinicopathological features, immunophenotype, differential diagnosis and prognosis of solid papillary carcinoma of the breast. Methods Clinicopathological data of 20 cases with solid papillary carcinoma of breast were collected and reviewed during January 2013 to October 2017 in Eastern District of Suzhou Municipal Hospital in Jiangsu Province. Immunohistochemical stainings were performed, clinicopathological feature was analyzed and follow-up was conducted. Results There were 19 females and 1 male with age between 40 and 78 years old [average of (61.8±7.9) years]. Immunohistochemical staining showed that the cases of expression of synaptophysin, chromograninA, and CD56 was 16, 10, 3, respectively. 6 cases presented with absence of myoepithelial cell markers. 14 cases had the follow-up data, and no one showed the recurrence or metastasis during the follow-up periods of 1-10 months. Conclusion With the distinctive histological features, immunophenotyping and clinicopathologic characteristics, solid papillary carcinoma has good prognosis and should be distinguished from the other papillary lesions of breast. Categorizing SPC without myoepithelial cells as in situ versus invasive carcinoma is not elucidated.
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2019, Vol. 16 
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