Stem cell transplantation for children with acquired severe aplastic anaemia
WANG Bin1 WU Runhui1 PANG Yilin2 ZHU Guanghua1 ZHOU Xuan1 YANG Jun1 LI Sidan1 QIN Maoquan1▲
1.Hematology Oncology Center, Beijing Children′s Hospital Affiliated to Capital Medical University Beijing Key Laboratory of Hematological Diseases and Tumor Molecular Classification National Key Discipline of Pediatrics, Beijing 100045, China;
2.Department of Emergency, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
Abstract：Objective To explore the effect of hematopoietic stem cell transplantation (HSCT) in the treatment of severe aplastic anemia, and evaluate its safety and prognosis. Methods Clinical data of 51 children with severe aplastic anaemia received HSCT in Hematology Department of Beijing Children′s Hospital Affiliated to Capital Medical University from January 2006 to December 2015 were retrospectively analyzed. The engraftment, complications and curative effect were evaluated. Results 98 percent of patients had rapid engraftment. The median time of neutrophil exceeded 0.5×109/L and platelets recovery exceeded 20×109/L were 11 and 15 days for all transplantation patients. In this research, 10 patients were diagnosed with CMV viremia. 2 patients developed hemorrhagic cystitis. 7 cases had grade Ⅰ-Ⅱ aGVHD and 2 cases had grade Ⅲ aGVHD. 46 patients were still alive. The estimated 3-year OS of the Allo-HSCT, Haplo-HSCT and MUD-HSCT group was 100%, 89% and 75% respectively. All children less than 5 years of age (without infection) were transplanted successfully. Conclusion HSCT is effective in the treatment of acute severe aplastic anemia in children, with fewer complications and high survival rates
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2017, Vol. 14 
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