Abstract：Objective To analyze the efficacy and safety of Pig Anti-Human Lymphocyte Globulin combined with Cyclosporin in the treatment of severe aplastic anemia. Methods A total of 30 cases hospitalized in Department of Hematology, the First People′s Hospital of Lianyungang City, Jiangsu Province from Apirl 2004 and December 2016 were enrolled into this study. The efficacy and safety of this treatment were analyzed, the overall survival by Kaplan-Meier method for this cohort of patients were estimated. Results The cohort of 30 patients was routinely followed up with a median follow-up of 60 (1-252) months, the median age was 26.5 (5-65) years old. Six died, the over response rate was 73.3%. The median time of the ANC＞0.5×109/L was 20 (2-40) days, transfusion of red blood cell independent was 30 (0-150) day, transfusion of palete independent was 30 (0-150) days, the 5-year survival rate was 78%. The response rate was high, but with less side effects and expense. Conclusion Long-term effect of Pig Anti-Human Lymphocyte Globulin combined with Cyclosporin in the treatment of severe aplastic anemia is significant, adverse reactions are mild, it is worthy of clinical promotion.
薛连国 毛建平 贾韬 王莹 陈泽 蔡志梅▲ 赵利东. 国产猪抗人淋巴细胞球蛋白联合环孢素治疗重型再生障碍性贫血的效果[J]. 中国医药导报, 2017, 14(20): 78-81.
XUE Lianguo MAO Jianping JIA Tao WANG Ying CHEN Ze CAI Zhimei▲ ZHAO Lidong. Effect of Pig Anti-Human Lymphocyte Globulin combined with Cyclosporin in the treatment of severe aplastic anemia. 中国医药导报, 2017, 14(20): 78-81.
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2017, Vol. 14 
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