Abstract：Objective To compare the influence of traditional Chinese medicine treatment and single western medicine treatment for the hemorheology indexes of patients with diabetic retinopathy by meta analysis. Methods The databases of PubMed, Medline, CBM disc, Cochrane library, CNKI, VIP, Wanfang, China Master's Theses Full-text Database and proceedings of the academic conference were retrieved. The retrieval time limit was from January 2000 to October 2016. The related clinical randomized controlled trials were researched, and the enrolled literatures were taken quality assessment and data extraction, and Revman5.3 software was used to take Meta analysis. Results In total, 26 clinical randomized controlled trials and 2421 patients were enrolled, with 1307 cases in experimental group and 1114 cases in control group. The levels of whole high blood viscosity (200/s) (SMD = -0.63, 95%CI: -0.91 - -0.34, P ＜ 0.01), whole low blood viscosity (5/s) (WMD = -0.76, 95%CI: -1.02 - -0.50, P ＜ 0.01), plasma viscosity (SMD = -0.62, 95%CI: -1.02 - -0.22, P = 0.002), fibrinogen (SMD = -0.67, 95%CI: -0.80 - -0.54, P ＜ 0.01), red blood cell aggregation index (SMD = -0.96, 95%CI: -1.46 - -0.47, P = 0.0001) in the experimental group were significantly lower than those of control group, the fundus changing curative effect (RR = 1.22, 95%CI: 1.17 - 1.28, P ＜ 0.01) and TCM syndrome curative effect (RR = 1.55, 95%CI: 1.18 - 2.03, P = 0.002) were significantly better than those of control group. The whole middle blood viscosity (30/s) between two groups had no statistically significant difference (MD = -1.22, 95%CI: -2.66 - 0.21, P = 0.10). Sensitivity analysis showed that the results were stable and reliable. Conclusion Traditional Chinese medicine treatment can reduce the whole high blood viscosity (200/s), whole low blood viscosity (5/s), plasma viscosity, fibrinogen, erythrocyte aggregation index of patients with diabetic retinopathy, and improve the fundus changing curative effect and TCM syndrome curative effect, all of which are superior to those of single western medicine treatment, while it has no effect on the whole middle blood viscosity (30/s). This paper shows that traditional Chinese medicine treatment for diabetic retinopathy has certain creative effect, but the methodological quality remains to be further improved, which needs more high-quality randomized, double-blind, controlled literatures to confirm.
陈秋野 马燕云 唐红. 中医药治疗对糖尿病性视网膜病变患者血液流变学指标影响的Meta分析[J]. 中国医药导报, 2017, 14(21): 175-180,184.
CHEN Qiuye MA Yanyun TANG Hong. Meta analysis on the influence of traditional Chinese medicine treatment for the hemorheology indexes of patients with diabetic retinopathy. 中国医药导报, 2017, 14(21): 175-180,184.
2017, Vol. 14 
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