Change of interleukin-17 levels in both synovial fluid and serum of patients with medial compartment knee osteoarthritis after proximal fibular osteotomy
BAI Yuming1 ZHANG Haisen1 LIU Chang1 JIN Shengli1 WANG Wenjie2 LIU Ying3 ZHANG Yanping3 LYU Zhichang4
1.The Second Department of Orthopaedics, Cangzhou Central Hospital, Hebei Province, Cangzhou 061001, China;
2.Emergency Drpartment, Cangzhou Central Hospital, Hebei Province, Cangzhou 061001, China;
3.Operating Room, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061001, China;
4.Department of Orthopaedics, People′s Hospital of Xian County, Hebei Province, Xian County 062250, China
Abstract：Objective To investigate interleukin-17 (IL-17) levels in both synovial fluid and serum of patients with medial compartment knee osteoarthritis (KOA) after proximal fibular osteotomy. Methods Thirty patients with medial compartment KOA underwent proximal fibular osteotomy at the Cangzhou Central Hospital from December 2014 to June 2015 were selected as experimental group, and 30 healthy individuals were selected as control group into the study. Visual analog pain score (VAS) and Knee Society score (KSS) were used to evaluate pain level and function of the experimental group. The IL-17 levels in both serum and synovial fluid of the experimental group at preoperative period and postoperative 6, 12, 18 months were measured by ELISA, also the serum levels of IL-17 in the control group were measured by ELISA. Results All incisions were healed in phase I. And all patients were followed up at least 18 months. The average tibiofemoral angle was (168.6±3.4)° at 18 months after surgery. Average postoperative VAS pain and KSS scores were significantly improved compared with preoperative period (P < 0.05), while there were no statistically significant differences during postoperative points (P > 0.05).The serum levels of IL-17 in the experimental group at different time points were higher than that in the control group (P < 0.05). The IL-17 levels in both serum and synovial fluid of the experimental group during postoperative points were decreased compared with preoperative period (P < 0.05), while there were no statistically significant differences during postoperative points (P > 0.05). Conclusion Proximal fibular osteotomy can significantly improve the pain symptoms and joint function of the patients with medial compartment KOA. It also can reduce the IL-17 levels in both synovial fluid and serum, while which can not back to healthy level.
白玉明1 张海森1 刘畅1 靳胜利1 王文杰2 刘颖3 张艳平3 吕志昌4. 腓骨近端截骨术治疗内侧间室膝骨关节炎术后白介素-17水平变化研究[J]. 中国医药导报, 2017, 14(21): 105-108.
BAI Yuming1 ZHANG Haisen1 LIU Chang1 JIN Shengli1 WANG Wenjie2 LIU Ying3 ZHANG Yanping3 LYU Zhichang4. Change of interleukin-17 levels in both synovial fluid and serum of patients with medial compartment knee osteoarthritis after proximal fibular osteotomy. 中国医药导报, 2017, 14(21): 105-108.
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2017, Vol. 14 
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