Effectiveness and safety of different application route of Tranexamic Acid in patients undergoing primary total hip arthroplasty
FAN Ya'nan1 WEN Yangyang1 ZHANG Leilei2 LI Wenlong1 ZHU Yingjie2 LIU Youwen2
1.Luoyang Working Department for Postgraduate Education, He'nan University of Chinese Medicine, He'nan Province, Zhengzhou 450046, China;
2.The Second Department of Hip Injury, He'nan Luoyang Orthopedic Traumatological Hospital Orthopaedic Hospital of He'nan Province, He'nan Province, Luoyang 471002, China
Abstract：Objective To investigate the application of two different routes of administration of Tranexamic Acid on the blood loss and its safety in patients with initial unilateral total hip arthroplasty (THA). Methods 90 patients with femoral head necrosis who need to undergo initial unilateral THA in He'nan Luoyang Orthopedic Traumatological Hospital were randomly divided into three groups by STATA software from October 2014 to August 2016 in Luoyang Orthopedic Hospital of He'nan. They were group A (staticly drop Tranexamic Acid before 10 minutes of the surgery), group B (injecting Tranexamic Acid after completion of surgery) and group C (without using Tranexamic Acid). The three groups of blood loss, postoperative drainage, invisible blood loss, total blood volume, the number of blood transfusions after surgery, blood transfusion and transfusion rate, the rate of deep vein thrombosis and pulmonary embolism after one week and one month follow-up were compared. Results The quantity of postoperative drainage, invisible blood loss, total blood volume, the number of blood transfusions after surgery, blood transfusion and transfusion rate differences were statistically significant (P < 0.05) among three groups, and the blood loss in the surgery had no statistically significant difference (P > 0. 05). Patients in the group C respectively 2 and 4 days after the surgery in 1 case between limb muscle, vein thrombosis and 2 cases of limb phil superficial vein thrombosis, pulmonary embolism was not occurred, who were timely received symptomatic treatment, with leaving hospital improved, after 1 month reviewing, color Doppler ultrasound prompted that the venous thrombosis had disappeared. The patients of group A and group B had not lower limb venous thrombosis and pulmonary embolism in postoperative 1 week and followed up for 1 month. Conclusion Preoperative intravenous and retrograde injection through the drainage tube application of Tranexamic Acid can significantly reduce the primary unilateral total hip arthroplasty in patients with postoperative blood loss and transfusion rate, and the recent security is a very high, and local injections of Tranexamic Acid is more safe and effective, without postoperative adverse reactions and complications.
范亚楠1 温阳阳1 张蕾蕾2 李文龙1 朱英杰2 刘又文2. 不同途径应用氨甲环酸对初次全髋关节置换术患者有效性及近期安全性研究[J]. 中国医药导报, 2017, 14(21): 97-100,116.
FAN Ya'nan1 WEN Yangyang1 ZHANG Leilei2 LI Wenlong1 ZHU Yingjie2 LIU Youwen2. Effectiveness and safety of different application route of Tranexamic Acid in patients undergoing primary total hip arthroplasty. 中国医药导报, 2017, 14(21): 97-100,116.
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2017, Vol. 14 
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