Abstract：Objective To investigate the relationship between serum fibroblast growth factor 23 (FGF23) and fetoprotein A (FA) levels and coronary artery calcification in patients with maintenance hemodialysis. Methods From April 2016 to April 2017, 97 cases of maintenance hemodialysis patients admitted to the Second Affiliated Hospital of Xi′an Jiaotong University were selected. All patients underwent MSCT, and according to coronary artery Agaston score (CACs), the patients were divided into non-calcification group (CACs＜10 points) 21 cases, mild calcification group (11 points≤CACs＜100 points) 33 cases, moderate calcification group (100 points≤CACs＜400 points) 24 cases, and severe calcification group (CACs＞400 points) 19 cases. Basic data and biochemical indexes of the patients in each group were compared, and correlation analysis was conducted. Results The age of patients in the severe calcification group was significantly higher than that in the non-calcification group, the mild calcification group and the moderate calcification group, and the duration of dialysis was longer than that in the non-calcification group, the mild calcification group and the moderate calcification group, and the duration of dialysis in the moderate calcification group was longer than that in the non-calcification group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the prevalence of diabetes, hypertension and gender composition among the groups (P ＞ 0.05). The levels of serum phosphorus and FGF23 in the non-calcification group, mild calcification group, moderate calcification group and severe calcification group presented a gradually increasing trend, while the level of serum FA presented a gradually decreasing trend, the differences between the groups were statistically significant (all P ＜ 0.05). Blood urea nitrogen, serum creatinine, glomerular filtration rate, fasting blood glucose, total cholesterol, triglyceride, and serum calcium were compared between groups, and the differences were not statistically significant (P ＞ 0.05). Pearson correlation analysis showed that the degree of coronary artery calcification in patients with maintenance hemodialysis was positively correlated with age, duration of hemodialysis, serum phosphorus and serum FGF23 level, while negatively correlated with serum FA level (all P ＜ 0.05). Conclusion Serum FGF23 and FA levels are closely related to coronary artery calcification in patients with maintenance hemodialysis, and with the increase of serum FGF23 level and the decrease of FA level, the degree of coronary artery calcification in patients with maintenance hemodialysis becomes more serious.
段朝阳1 林燕2 高洁1 韩锦1 马晓桃1 卢家美1 吕治安1 王莉1. 血清FGF23、FA水平与维持性血液透析患者冠状动脉钙化的关系[J]. 中国医药导报, 2019, 16(14): 117-120.
DUAN Chaoyang1 LIN Yan2 GAO Jie1 HAN Jin1 MA Xiaotao1 LU Jiamei1 LYU Zhian1 WANG Li1. Relationship between serum FGF23 and FA level and coronary artery calcification in patients with maintenance hemodialysis. 中国医药导报, 2019, 16(14): 117-120.
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2019, Vol. 16 
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