Analysis of postoperative infection and related factors in patients with cardiothoracic surgery ICU
LIU Danwei NI Guangsheng YANG Jin XU Zhaojun
Department of Cardiothoracic Surgery, the First Affiliated Hospital of Hu′nan University of Traditional Chinese Medicine, Hu′nan Province, Changsha 410007, China
Abstract：Objective To investigate postoperative infection and related risk factors in patients with cardiothoracic surgery ICU. Methods A retrospective analysis was made on 240 patients admitted to ICU of Cardiothoracic Surgery, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from July 2016 to July 2018. The clinical data (including age, cardiopulmonary bypass, time of tracheal intubation, time of drainage tube placement, time of catheter placement, operation time, blood transfusion, time of deep vein catheterization) and monitoring funds of nosocomial infection were collected. The data were systematically investigated and analyzed. Results Hospital infection occurred in 38 of 240 patients, with an infection rate of 15.83%. The most common site of infection is the respiratory tract, a total of 25 cases. Fifty-nine strains of pathogens were detected, including 34 Gram-negative bacteria, 15 Gram-positive bacteria, and 10 fungi. Multivariate Logistic regression analysis showed that age, extracorporeal circulation, tracheal intubation time, and drainage tube placement time were independent risk factors for postoperative infection, and the differences were statistically significant (P < 0.05). The main Gram-negative bacteria were Acinetobacter baumannii and Klebsiella pneumoniae, which were more resistant to Cefixime, Imipenem, Ciprofloxacin, Gentamicin, Ampicillin and Aztreonam. Gram-positive bacteria were mainly Staphylococcus haemolyticus, Staphylococcus epidermidis and Staphylococcus hemorrhagicus. Gram-positive bacteria mainly include Staphylococcus haemolyticus, Staphylococcus epidermidis, and Staphylococcus aureus, which were sensitive to Vancomycin and Linezolid, but they were resistant to Amoxicillin, Azithromycin, Deoxycephalosporin, Meropenem, and Cefixime, with higher resistance rate. Conclusion The infection rate of ICU patients in cardiothoracic surgery is high, and there are many factors leading to infection. The clinical intervention should be given. The drug resistance rate of pathogenic bacteria is relatively high. Clinical attention should be paid to the detection of pathogenic microorganisms, and rational use of antibiotics should be based on the results of bacterial culture and drug sensitivity.
刘丹薇 倪广生 杨进 徐朝军. 心胸外科ICU患者术后感染及相关因素分析[J]. 中国医药导报, 2019, 16(14): 113-116.
LIU Danwei NI Guangsheng YANG Jin XU Zhaojun. Analysis of postoperative infection and related factors in patients with cardiothoracic surgery ICU. 中国医药导报, 2019, 16(14): 113-116.
2019, Vol. 16 
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