Study on the correlation of plasma suPAR and D-dimer levels with plaque vulnerability in patients with atherosclerosis cerebral infarction
ZOU Lan1 LI Guoliang1 YAN Xiaoxin2
1.Department of Neurology, Xiangya Hospital of Central South University, Hu′nan Province, Changsha 410005, China;
2.School of Basic Medicine, Central South University, Hu′nan Province, Changsha 410013, China
Abstract：Objective To measure the levels of soluble urokinase plasminogen activator receptor (suPAR) and D-dimer in patients with atherosclerotic cerebral infarction (ACI), and to explore the correlation between them and carotid plaque stability. Methods The clinical data of 90 patients with ACI admitted to Xiangya Hospital of Central South University from January 2017 to January 2018 was retrospectively analyzed and the patients were divided into instability plaque group (42 cases) and unstable plaques group (48 cases) by stability of carotid atherosclerosis. While 50 cases of outpatient health examinations were selected as control group at the same time. The plasma suPAR and D-dimer levels were detected and compared among the three groups. The correlation of plasma suPAR and D-dimer levels with carotid plaque stability was analyzed. Results ①The difference in suPAR and D-dimer expression among three groups was statistically significant (P ＜ 0.01), suPAR and D-dimer levels in the unstable plaque group were significantly higher than those in the stable plaque group and the control group (P ＜ 0.01), and suPAR and D-dimer levels in the plaque stability group were significantly higher than those in the control group (P ＜ 0.01). ②suPAR and D-dimer were risk factors for plaque stability [OR = 1.068, 95%CI (0.002-0.215), P ＜ 0.05; OR = 1.013, 95%CI (0.014-0.462), P ＜ 0.05]. ③The optimal cut-off point for suPAR to predict the unstability of carotid plaques was 8.04 ng/mL. The area under the ROC curve was 0.660 (95%CI: 62.7%-96.5%, P ＜ 0.05). The optimal cut-off point for D-dimer to predict the unstability of carotid plaques was 3.92 ng/mL. The area under the ROC curve was 0.837 (95%CI: 66.1%-99.8%, P ＜ 0.05). Conclusion suPAR and D-dimer can be indicators to evaluate carotid plaque stability in patients with atherosclerotic cerebral infarction.
邹兰1 李国良1 严小新2. 血浆中suPAR和D-二聚体水平与动脉粥样硬化性脑梗死患者斑块易损性相关研究[J]. 中国医药导报, 2019, 16(14): 47-50.
ZOU Lan1 LI Guoliang1 YAN Xiaoxin2. Study on the correlation of plasma suPAR and D-dimer levels with plaque vulnerability in patients with atherosclerosis cerebral infarction. 中国医药导报, 2019, 16(14): 47-50.
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2019, Vol. 16 
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