Abstract：DNA methylation modification is a hot research topic in epigenetics. Its involved in regulating gene expression, gene silencing, DNA damage repair, and cancer, and other important biological processes, most of the pathogenic process of cancer, immune system diseases, Alzheimer′s disease are involved in epigenetic changes, gene methylation is mainly in the areas rich in GC base sequence of the CpG, gene under the action of the corresponding methylation transferase regulate the expression of cancer gene, oncogene and DNA damage repair, etc. In this paper, the significance and research progress of DNA methylation in gene expression regulation in genome were reviewed.
[1] Cui D，Xu X. DNA Methyltransferases，DNA Methylation，and Age-Associated Cognitive Function [J]. Int J Mol Sci，2018，19（5）.pii：E1315.
[2] Araujo OC，Rosa AS，Fernandes A，et al. RASSF1A AND DOK1 promoter methylation levels inhepatocellular carcinoma，cirrhotic andnon-cirrhotic liver，and correlation wiht liver cancer in brazilian patients [J]. PLoS One，2016，（4）：e0153796.
[3] Toshinori H，Weisenberger DJ，Lange CPE，et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer [J]. Genome Res，2012，22（2）：271-282.
[4] Guo X，Wang L，Li J，et al. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A [J]. Nature，2015，517（7536）：640-644.
[5] Moore LD，Le T，Fan G. DNA methylation and its basic function [J]. Neuropsychopharmocology，2013，38（1）：23-38.
[6] 霍中军，陈芳，罗自勉.DNA甲基转移酶3A基因与肿瘤发生的分子调控机制研究进展[J].现代肿瘤医学，2018， 26（20）：3325-3329.
[7] Subramaniam D，Thombere R，Dhar A，et al. DNA methyl-transferase：a novel target for prevention and therapy [J]. Front Oncol，2014，4（4）：80.
[8] Bethge N，Lothe RA，Honne H，et al. Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma [J]. Epigenetics，2014，9（3）：428-836.
[9] 李江.多发性骨髓瘤相关基因DAZAP2启动子甲基化初步研究及抗DAZAP2多克隆抗体制备[D].湖南：中南大学，2010：1-63.
[10] 张琪.宫颈肿瘤相关局势细胞中IL-10基因的转录调控表达机制研究[D].河北：华北理工大学，2017：1-57.
[11] Moison C，Senamaud-Beaufort C，Fourriere L，et al. DNA methylation associated with polycomb repression in retinoic acid receptor β silencing [J]. FASEB J，2013，27（4）：1468-1478.
[12] Zhao X，Wang N，Zhang M，et al. Detection of methylation of the RAR-βgene in patients with non-small cell lung cancer[J]. Oncol Lett，2012，3（3）：654-658.
[13] 朱鹏.泛发性脓疱型银屑病患者DNA甲基化相关研究及临床分析[D].北京：北京协和医院，2017：1-109.
[14] Symington LS，Gautier J. Double-strand break end resection and repair pathway choice [J]. Annu Rev Genet，2011，45：247-271.
[15] Li F，Mao G，Tong D，et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its inter-action with MutSa [J]. Cell，2013，153（3）：590-600.
[16] Hassler MR，Pulverer W，Lakshminarasimhan R，et al. Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling [J]. Cell Rep，2016，17（2）：596-608.
[17] Guo S，Diep D，Plongthongkum N，et al. Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA [J]. Nat Genet，2017，49（4）：635-642.
[18] Wysocki K，Conley Y，Wenzel S. Epigenome variation in severe asthma [J]. Bio Res Nurs，2015（17）：263-269.
[19] Tanday S. Epigenetic study identifies gene linked to asthma and allery [J]. Lancet Respir Med，2015（3）：274.
[20] Qiu H，Sarathy A，Schulten K，et al. Detection and Mapping of DNA Methylation with 2D Material Nanopores [J]. NPJ 2D Mater Appl，2017，1：3.
[21] Shinagawa S，Kobayashi N，Nagata T，et al. DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer′s disease and amnesic mild cognitive impairment patients [J]. Neurosci Lett，2016，629：33-37.
[22] 刘桂利.轻度认知障碍候选基因的DNA甲基化研究[D].宁波：宁波大学，2017：68.
[23] North ML，Ellis AK. The role of epigenetics in thedevelopmental origins of allergic disease [J]. Ann Allergy Asthma Immunol，2011，106（5）：355-361.
[24] Wahl S，Drong A，Lehne B，et al. Epigenome-wide association study of body mass index，and the adverse outcomes of adiposity [J]. Nature. 2017，541（7635）：81-86.
[25] Reynolds LM，Taylor JR，Ding J，et al. Age-related variations in the methylome associated with gene expression in human monocytes and T cells [J]. Nat Commun，2014， 5：5366.
2019, Vol. 16 
京公网安备 11010502046598号