Abstract：Objective To explore and analyze the malignant risk factors of video-assisted thoracoscopic surgery (VATS) for small pulmonary nodules and its effect on immune function. Methods Eighty patients with small pulmonary nodules admitted to Anhui Provincial Thoracic Hospital from June 2016 to June 2018 were treated with VATS, and definite pathological diagnosis was obtained. The malignant risk factors of small pulmonary nodules were analyzed. After VATS treatment for both benign and malignant pulmonary nodules, the changes of immune function in perioperative period were compared. Results Age, nodule maximum diameter, spiculation sign, lobulation sign, pleural traction sign, cavity sign, vascular cluster sign and calcification sign were included in the Logistic regression analysis. The results showed that age, nodule maximum diameter, spiculation sign, lobulation sign and pleural traction sign could be used as independent correlative factors to judge the malignancy of pulmonary nodules (P ＜ 0.05). All the patients were operated smoothly, and no serious complications or deaths were found during the perioperative period. The levels of CD4+, CD8+, CD4+/CD8+ and natural killer cells decreased before and after operation for benign and malignant pulmonary nodules (P ＜ 0.05). Conclusion Age, maximum diameter of nodules, spiculation sign, lobulation sign and pleural traction are independent factors in the determination of malignant pulmonary nodules. VATS treatment of pulmonary nodules can inhibit the acute inflammatory response after operation, and does not have a strong inhibitory effect on the immune function of patients, with high safety.
周胜年 马冬春 陈兵. 电视胸腔镜手术治疗肺小结节的恶性危险因素分析及对机体免疫功能的影响[J]. 中国医药导报, 2019, 16(13): 91-94.
ZHOU Shengnian MA Dongchun CHEN Bing . Analysis of the risk factors for the treatment of pulmonary nodules by video-assisted thoracoscopic surgery and its effect on immune function. 中国医药导报, 2019, 16(13): 91-94.
2019, Vol. 16 
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