Hemostatic effect of three different hemostasis methods in the model of anorectal hemorrhage in rats
WU Xiaoyan1 DENG Bo2 LIU Minyong3 He Bin4 HUANG Chengzi1 ZHEN Linzhi1 HE Yuzhi1 LI Jun4
1.The Clinical Medical College of Southwest Medical University, Sichuan Province, Luzhou 646000, China;
2.Department of Nursing, Southwest Medical University, Sichuan Province, Luzhou 646000, China;
3.Department of Nursing Research, Southwest Medical University, Sichuan Province, Luzhou 646000, China;
4.Department of Anorectum, the Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou 646000, China
Abstract：Objective To evaluate the hemostatic effect of three different hemostatic methods in the model of anorectal bleeding in rats. Methods Twenty-seven SPF SD male rats only randomized block design was divided into air tract tourniquet group (group A) and gelatin sponge group (group B), vaseline oil gauze group (group C), each group of nine, hemorrhage model was established, with balloon tourniquet pressure cavity, vaseline oil gauze or gelatin sponge tamponade hemostasis, press 4 min, for the first time and then every 2 min to check bleeding to stop bleeding, observe the bleeding time, blood loss, after the success of the hemostatic, observe 5 min to assess any bleeding again. Two days after surgery, hematoxylin - eosin staining was used to observe the inflammation. Results Compared with group C and B, group A had shorter hemostasis time and less blood loss, and the difference was statistically significant (P ＜ 0.01). Compared with group B, the blood loss in group C was lower, and the difference was statistically significant (P ＜ 0.05).There was no statistically significant difference between the three hemostasis methods for re-bleeding within 5 min (P ＞ 0.05). Histological sections showed the most severe inflammatory response in group C. Conclusion The most effective hemostasis method is the balloon cavity hemostatic device, followed by vaseline gauze, gelatin sponge used alone has poor hemostatic effect.
吴晓艳1 邓波2 刘珉甬3 何彬4 黄橙紫1 郑淋之1 何裕智1 李俊4. 三种不同止血方法在大鼠肛管直肠出血模型中的止血效果[J]. 中国医药导报, 2019, 16(13): 24-28.
WU Xiaoyan1 DENG Bo2 LIU Minyong3 He Bin4 HUANG Chengzi1 ZHEN Linzhi1 HE Yuzhi1 LI Jun4. Hemostatic effect of three different hemostasis methods in the model of anorectal hemorrhage in rats. 中国医药导报, 2019, 16(13): 24-28.
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2019, Vol. 16 
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