Prognostic value of CK-MB, cTnI, BNP, BUN and cystatin in patients with carbon monoxide poisoning
JIN Lili1 QIE Tao2 ZHANG Tongle1 LI Liqin3 LIANG Qing2 TIAN Xiang4
1.the Fifth Department of Cardiology, Baoding First Central Hospital, Hebei Province, Baoding 071000, China;
2.Department of Emergency, Baoding First Central Hospital, Hebei Province, Baoding 071000, China;
3.the First Department of Endocrinology, Baoding First Central Hospital, Hebei Province, Baoding 071000, China;
4.the Second Department of Cardiology, Baoding First Central Hospital, Hebei Province, Baoding 071000, China
Abstract：Objective To explore the prognostic value of creatine kinase isozyme (CK-MB), serum troponin (cTnI), brain natriuretic peptide (BNP), urea nitrogen (BUN), cystatin in patients with carbon monoxide poisoning. Methods From October 2016 to March 2018, 136 patients with acute carbon monoxide poisoning treated in the First Central Hospital of Baoding City were selected as the study subjects. According to the clinical prognosis, the patients were divided into good prognosis group (n = 122) and poor prognosis group (n = 14). The levels of CK-MB, cTnI, BNP, BUN and cystatin were compared and analyzed between the two groups at admission and 7 days after admission. Results The levels of CK-MB, BNP and cystatin were significantly lower in the good prognosis group than in the poor prognosis group, and the differences were highly statistically significant (P < 0.01). The levels of CK-MB, cTnI, BNP, BUN and cystatin in the good prognosis group and the poor prognosis group were significantly lower than those at admission, and the differences were statistically significant (P < 0.05). The levels of cTnI, BNP and cystatin in the good prognosis group were significantly lower than those in the poor prognosis group 7 days after admission, and the differences were highly statistically significant (P < 0.01). The correlations between BNP levels at admission and 7 days after admission and the prognosis of carbon monoxide poisoning were good. The areas under the curve were 0.861 and 0.856, respectively, which were much higher than the area under the curve of other indicators. The specificity and sensitivity of BNP at admission were 71.4% and 91.8%, respectively. The specificity and sensitivity of BNP 7 days after admission for were 64.3% and 97.5%, respectively, which were higher than other indicators. Conclusion The level of BNP in patients with carbon monoxide poisoning at admission and after treatment has a good correlation with the prognosis of carbon monoxide poisoning. It has good specificity and sensitivity, and can be used as an effective marker to judge the prognosis of patients with carbon monoxide poisoning.
2019, Vol. 16 
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