Abstract：Objective To study the diagnostic value of serum micro RNA-6861-5p (miR-6861-5p) combined with carbohydrate antigen 153 (CA153) in breast cancer. Methods A total of 83 cases of breast cancer patients admitted to Anshan Tumor Hospital (hereinafter referred to as “our hospital”) from April 2015 to April 2018 were selected, which were recorded as the breast cancer group. In addition, 80 patients with benign breast diseases who received diagnosis and treatment in our hospital during the same period were selected as the benign breast disease group, and 80 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression of serum miR-6861-5p in each group, and the serum CA153 level was detected by chemiluminescence. The levels of serum miR-6861-5p and CA153 in the three groups were compared, and the relationship between the above two indicators and the clinicopathological characteristics of breast cancer patients was analyzed. The diagnostic efficacy of serum miR-6861-5p combined with CA153 levels in breast cancer was analyzed using the receiver operating characteristic (ROC) curve. Results The levels of serum miR-6861-5p and CA153 in the breast cancer group were higher than those in the benign breast disease group and the control group, with statistically significant differences (all P < 0.05). Ⅰ-Ⅱ period with no lymph node metastasis of breast cancer patients serum miR - 6861-5 P levels were lower than Ⅲ-Ⅳ period and the patients with lymph node metastasis, the differences were statistically significant (all P < 0.05). Ⅰ-Ⅱ period with no lymph node metastasis of breast cancer patients serum CA153 levels were lower than Ⅲ-Ⅳ period and the patients with lymph node metastasis, the differences were statistically significant (all P < 0.05). The sensitivity and specificity under the curve of miR-6861-5p combined with CA153 in diagnosis of breast cancer were all higher than those of miR-6861-5p and CA153 alone (all P < 0.05). Conclusion The application of serum miR-6861-5p combined with CA153 detection in breast cancer patients has high diagnostic efficacy, and can be used as an effective means for clinical diagnosis of breast cancer.
付红伟 董禹洋. 血清miR-6861-5p联合CA153对乳腺癌的诊断价值[J]. 中国医药导报, 2019, 16(5): 92-95.
FU Hongwei DONG Yuyang. Diagnostic value of serum miR-6861-5p combined with CA153 for breast cancer. 中国医药导报, 2019, 16(5): 92-95.
2019, Vol. 16 
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