Correlation analysis of serum 25 hydroxyvitamin D3, antimicrobial peptide LL-37, and interleukin-6 with disease severity in children with bronchiolitis
LYU Yanguan1 ZHANG Qigang1 LIN Xiaofei2 ZANG Xiaojuan3
1.Department of Laboratory, Huaian Maternal and Child Health Hospital Affiliated to Yangzhou University, Jiangsu Province, Huaian 223002, China; 2.Department of Pediatric Internal Medicine, Huaian Maternal and Child Health Hospital Affiliated to Yangzhou University, Jiangsu Province, Huaian 223002, China; 3.Department of Ultrasonography, Huaian Maternal and Child Health Hospital Affiliated to Yangzhou University, Jiangsu Province, Huaian 223002, China
Abstract：Objective To investigate the correlation of serum 25-hydroxyvitamin D3 (25-[OH]D3), antimicrobial peptide LL-37, and interleukin-6 (IL-6) with disease severity in children with bronchiolitis. Methods Sixty cases with bronchiolitis admitted to Huaian Maternal and Child Health Hospital Affiliated to Yangzhou University from October 2021 to October 2022 were selected as the experimental group, the control group was selected from 60 healthy children who underwent physical examination in the same period. According to the diagnostic criteria of bronchiolitis, they were divided into mild group and severe group, with thirty cases in each group. The serum levels of 25-[OH]D3, LL-37, and IL-6 in all groups were compared; the correlation between the levels of serum 25-[OH]D3, LL-37, and IL-6 and the severity of bronchiolitis in children with bronchiolitis were analyzed. Results The levels of serum 25-[OH]D3 and LL-37 in experimental group were lower than those in control group, while the level of IL-6 was higher than that in control group (P＜0.05). The serum levels of 25-[OH]D3 and LL-37 in severe group were lower than those in mild group (P＜0.05); there was no statistical significance in the level of IL-6 between severe group and mild group (P＞0.05). The levels of serum 25-[OH]D3 and LL-37 were negatively correlated with the severity of bronchiolitis in children (r=-0.563, -0.681, P＜0.05); the level of serum IL-6 was positively correlated with the severity of bronchiolitis in children (r=0.645, P＜0.05). Conclusion The levels of serum 25-[OH]D3, LL-37, and IL-6 are related to the occurrence of bronchiolitis. The levels of serum 25-[OH]D3, LL-37, and IL-6 can indicate the degree of bronchiolitis, this study can provide new ideas for the diagnosis and treatment of children with bronchiolitis.
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2023, Vol. 20 
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