Research progress on the mechanism of damage of asymptomatic hyperuricemia to vascular endothelial function
WU Xiaowen1 ZHU Xiaolin2 YANG Yali2 YIN Liping2
1.Graduate School, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China; 2.Department of Nephrology, the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210017, China
Abstract：Asymptomatic hyperuricemia is a metabolic disorder characterized by elevated levels of serum uric acid. Elevated uric acid stimulates the inflammatory process, promotes oxidative stress, reduces nitric oxide bioavailability, activates the renin-angiotensin system, induces changes in mitochondrial function, and causes endothelial dysfunction, accelerating the progression of chronic kidney disease, cardiovascular system disease, metabolic disease, and other chronic diseases. This article elaborates on the mechanism of high-level uric acid damage to vascular endothelium, in order to provide new ideas for clinical diagnosis and treatment.
吴小雯1 朱晓琳2 杨亚丽2 殷立平2. 无症状高尿酸血症对血管内皮功能的损害机制的研究进展[J]. 中国医药导报, 2023, 20(36): 46-49.
WU Xiaowen1 ZHU Xiaolin2 YANG Yali2 YIN Liping2. Research progress on the mechanism of damage of asymptomatic hyperuricemia to vascular endothelial function. 中国医药导报, 2023, 20(36): 46-49.
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2023, Vol. 20 
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