Abstract:Objective To evaluate the clinical effect of different acupuncture therapies for sudden deafness by mesh meta-analysis. Methods Randomized controlled trials on acupuncture and moxibustion in treatment of sudden deafness were searched from PubMed, Embase, Cochrane Library, CNKI, Wanfang Data, VIP, and SinoMed database, and the search time was from inception to March 2023. Stata17.0 was used for mesh meta-analysis. Results A total of 23 articles were included, covering six different interventions. The total response rate included six interventions and the average hearing threshold included four interventions. In terms of total effective rate, filiform needle (OR=4.00, 95%CI: [1.37 to 11.70]), filiform needle + conventional western medicine (OR=3.86, 95%CI:[2.54 to 5.87]), electro-acupuncture (OR=3.09, 95%CI:[1.61 to 5.92]), electro-acupuncture + conventional western medicine (OR=5.14, 95%CI:[1.86 to 14.19]), acupoint injection + conventional western medicine (OR=3.38, 95%CI:[1.94 to 5.89]) were superior to conventional western medicine. In terms of average hearing threshold, filiform needle + conventional western medicine (OR=-1.90, 95%CI: [-2.99 to -0.81]), electro-acupuncture + conventional western medicine [OR=-3.55, 95%CI: (-6.50 to -0.61)] were superior to conventional western medicine. Total effective rate: electro-acupuncture + conventional western medicine > filiform needle + conventional western medicine > filiform needle > acupoint injection + conventional western medicine > electro- acupuncture > conventional western medicine; average hearing threshold: electro-acupuncture + conventional western medicine > filiform needle + conventional western medicine > acupoint injection + conventional western medicine > conventional western medicine. Conclusion Acupuncture ther- apy or acupuncture therapy combined with conventional western medicine is better than conventional western medicine in the treatment of sudden deafness, and electro-acupuncture com- bined with conventional western medicine has advantages in improving the average hearing threshold and total effective rate.