Abstract：Objective To investigate the relationship between serum melatonin (MT), osteopontin (OPN) levels, and cerebral vasospasm (CVS) after intracranial aneurysm rupture. Methods A total of 149 patients with intracranial aneurysm rupture admitted to Guangdong Sanjiu Brain Hospital from March 2017 to October 2022 for concurrent surgical treatment were selected as the study objects, and they were divided into CVS group (60 cases) and non-CVS(NCVS) group (89 cases) according to whether the patients had concurrent CVS after surgery. The differences of serum MT, OPN levels, and other clinical data between the two groups were compared. The influencing factors of postoperative CVS were analyzed by logistic regression model, and the predictive value of MT and OPN on postoperative CVS was calculated by receiver operating characteristic (ROC) curve. Results The proportion of Fisher Grade three to four, the proportion of World Federation of Neurosurgical Societies Grade three to four, and serum MT, OPN in CVS group were higher than those in NCVS group, and the Glasgow coma scale score was lower than that in NCVS group, the differences were statistically significant (P＜0.05). Logistic regression model analysis showed that serum levels of MT (OR=2.303, 95%CI: 1.517-3.496) and OPN (OR=2.494, 95%CI: 1.383-4.499) were independent influencing factors for postoperative CVS in patients with ruptured intracranial aneurysm (P＜0.05). ROC curve analysis showed that the area under the curve predicted by MT and OPN was higher than that predicted by them alone (P＜0.05). Conclusion Serum MT and OPN levels in patients with CVS after intracranial aneurysm rupture are significantly increased, both of which are independent risk factors for patients with CVS after surgery. Combined detection is helpful for early evaluation of patients with CVS after surgery.
2023, Vol. 20 
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