Diagnostic value of serum CD40 ligand and QTc interphase level in postoperative arrhythmia of coronary heart disease
ZHANG Qian1 LI Xiaolong2 JIN Mengxue1▲
1.Department of Functional Examination, Suzhou Hospital of Integrated Chinese and Western Medicine, Jiangsu Province, Suzhou 215000, China; 2.Department of Internal Medicine, Wuzhong District Mudu Town Community Health Service Center, Jiangsu Province, Suzhou 215000, China
Abstract：Objective To explore the diagnostic value of serum CD40 ligand (CD40L) combined with QTc interphase level of ambulatory electrocar-diogram in postoperative arrhythmia of coronary heart disease. Methods A total of 89 patients with coronary heart disease admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2020 to January 2022 were selected. Clinical medical records of the patients were collected and collated, and ambulatory electrocar-diogram and CD40L levels were detected after admission. According to the occurrence of arrhythmia within one month after percutaneous coronary intervention, the patients were divided into occurrence group (ten cases) and non-occurrence group (79 cases). Logistic regression model was used to analyze the influencing factors of postoperative arrhythmia, and the diagnostic value of QTc interphase level and serum CD40L level in arrhythmia was further evaluated by receiver operating characteristics (ROC) curve. Results The levels of serum potassium, QTc interphase level, and CD40L in the occurrence group were higher than those in the non-occurrence group, the differences were statistically significant (P＜0.05). Analysis of influencing factors showed that blood potassium (OR=3.684, 95%CI: 1.259-5.685), QTc interval (OR=2.743, 95%CI: 1.259-6.666), and serum CD40L (OR=3.340, 95%CI: 1.374-8.118) were the influential factors for postoperative arrhythmia in patients with coronary heart disease (P＜0.05). ROC curve analysis showed that the combined QTc interphase level of ambulatory electrocar-diogram, and serum CD40L level were more effective in diagnosing arrhythmias than those predicted by them alone (P＜0.05). Conclusion The QTc interphase level of ambulatory electrocar-diogram and serum CD40L are abnormal in patients with post-coronary heart disease arrhythmia, and the levels of serum CD40L combined with QTc interphase level are of high diagnostic value for postoperative arrhythmia of coronary heart disease.
2023, Vol. 20 
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