出血性脑卒中与细胞焦亡相关研究进展

doi:10.20047/j.issn1673-7210.2023.34.13

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摘要出血性脑卒中是一类高致死率、高致残率的严重疾病，包括脑实质出血和蛛网膜下腔出血，对患者的生命和生活质量造成严重危害。细胞焦亡是一种促炎性细胞死亡的方式，近年来研究发现细胞焦亡在脑卒中的生理病理过程中扮演者重要的角色，是减轻脑卒中后炎症反应和恢复神经功能的潜在治疗靶点，但对于细胞焦亡在出血性脑卒中后细胞死亡和炎症反应中发挥的作用与机制的论述相对较少。本文通过论述细胞焦亡分子机制及其与其他细胞死亡方式的区别，归纳近年来发表的文献中与细胞焦亡与出血性脑卒中的相关分子的实验研究，探索细胞焦亡在出血性脑卒中神经细胞死亡和炎症反应中所发挥的作用。

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	郭佩鑫1　　邹伟2

关键词 ：细胞焦亡, 出血性脑卒中, 脑实质出血, 蛛网膜下腔出血

Abstract：Hemorrhagic stroke is a serious disease with a high mortality and disability rate, including intracerebral hemorrhage and subarachnoid hemorrhage, which poses a serious threat to the life and quality of life of patients. Pyroptosis is a kind of proinflammatory cell death. In recent years, studies have found that pyroptosis plays an important role in the physiological and pathological process of stroke, and is a potential therapeutic target to reduce inflammatory response and restore neurological function after stroke. However, there are relatively few discussions on the role and mechanism of pyroptosis in cell death and inflammatory response after hemorrhagic stroke. This article discusses the molecular mechanism of pyroptosis and its difference from other cell death modes, summarizes the experimental studies on the molecules related to pyroptosis and hemorrhagic stroke in the published literature in recent years, and explores the role of pyroptosis in the neuronal death and inflammatory response of hemorrhagic stroke.

Key words： Pyroptosis Hemorrhagic stroke Intracerebral hemorrhage Subarachnoid hemorrhage

基金资助:黑龙江省中医药管理局省级名中医专家传承工作室建设项目。

通讯作者: 邹伟（1965-），男，博士，博士生导师，主任医师，黑龙江中医药大学附属第一医院副院长；研究方向：中西医结合治疗脑病。

作者简介: 郭佩鑫（1993-），男，黑龙江中医药大学第一临床医学院2020级中西医结合临床专业在读博士研究生；研究方向：中西医结合治疗脑病。

引用本文:

郭佩鑫1　　邹伟2. 出血性脑卒中与细胞焦亡相关研究进展[J]. 中国医药导报, 2023, 20(34): 61-64.
GUO Peixin1 ZOU Wei2. Research progress on the relationship between hemorrhagic stroke and pyroptosis. 中国医药导报, 2023, 20(34): 61-64.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.34.13 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I34/61

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