Current status of research on treatment of knee osteoarthritis with platelet-rich plasma based on Wnt/β-catenin signaling pathway
DENG Lei1 WANG Shaohua2 HOU Yingzhou2 YANG Guangya1 LI Kewei2 SUN Bo2
1.The First Clinical Medical College, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450003, China; 2.Department of Joint Surgery, Zhengzhou Orthopedic Hospital, Henan Province, Zhengzhou 450003, China
Abstract：Knee osteoarthritis (KOA) is a chronic degenerative bone disease characterized by the wear of articular cartilage. In the early stage, the main manifestations are knee pain, swelling, and limited joint movement, which can eventually lead to locking of the knee, deformity, and disability. Wnt/β-catenin signaling pathway plays an important role in the pathogenesis and development of KOA, which influences the metabolic balance of articular cartilage and subchondral bone by regulating cell proliferation and differentiation. Platelet-rich plasma (PRP), as a new treatment for KOA, can slow down the pathologic progression of KOA by delaying cartilage degeneration, promoting cartilage regeneration, and inhibiting intra-articular inflammation, which may be related to its involvement in the regulation of Wnt/β-catenin signaling pathway. This article mainly introduces the pathological relationship between Wnt/β-catenin signaling pathway and KOA, the application of PRP in the treatment of KOA, and the research status of PRP based on Wnt/β-catenin pathway in the treatment of KOA, aiming to provide more theoretical basis for the clinical treatment of KOA with PRP.
邓磊1 王少华2 侯颖周2 杨光亚1 李科伟2 孙博2. 富血小板血浆基于Wnt/β-catenin信号通路治疗膝骨关节炎的研究现状[J]. 中国医药导报, 2023, 20(34): 53-56.
DENG Lei1 WANG Shaohua2 HOU Yingzhou2 YANG Guangya1 LI Kewei2 SUN Bo2. Current status of research on treatment of knee osteoarthritis with platelet-rich plasma based on Wnt/β-catenin signaling pathway. 中国医药导报, 2023, 20(34): 53-56.
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2023, Vol. 20 
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