Effects of C1q/TNF-related protein 3, matrix metalloproteinase 3, and matrix metalloproteinase 9 on bone mineral density in postmenopausal women
LU Xuechao1 XU Yuanyuan1▲ WEI Yingfeng1 REN Yali2 WANG Xia3
1.Department of Endocrinology, Nantong Third People’s Hospital Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226000, China; 2.Department of Medical Technology, Nantong Health Higher Vocational and Technical School, Jiangsu Province, Nantong 226000, China; 3.Department of Osteoporosis, Nantong Third People’s Hospital Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226000, China
Abstract：Objective To investigate the effects of C1q/ TNF-related protein 3 (CTRP3), matrix metalloproteinase (MMP)-3, and MMP-9 on bone mineral density in postmenopausal women. Methods The clinical data of 92 women with natural men- opause who underwent physical examination in Nantong Third People’s Hospital of Jiangsu Province from June 2019 to June 2022 were retrospectively analyzed. They were divided into healthy group and osteoporosis group according to bone mineral density T score, osteoporosis was defined as bone mineral density T score≤-2.5 SD. The levels of CTRP3, MMP-3, and MMP-9 were compared between two groups. The correlation between CTRP3, MMP-3, and MMP-9 and bone mineral density was analyzed by Pearson correlation analysis, and the predictive value of CTRP3, MMP-3, and MMP-9 in osteoporosis was evaluated by receiver operation characteristic curve. Results Bone mineral density and bone mineral content of lumbar spine and femoral neck in osteoporosis group were lower than those in healthy group (P＜0.05). The level of CTRP3 in osteoporosis group was lower than that in healthy group, and the levels of MMP-3 and MMP-9 in osteoporosis group were higher than those in healthy group (P＜0.05). CTRP3 was positively correlated with bone mineral density of lumbar spine and femoral neck (r=0.451, 0.483, P＜0.05); MMP-3 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.476, -0.439, P＜0.05); MMP-9 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.508, -0.449, P＜0.05). The area under the curve predicted jointly by CTRP3, MMP-3, and MMP-9 was higher than that predicted by each index alone. Conclusion CTRP3, MMP-3, and MMP-9 levels are correlated with bone mineral density in postmenopausal women and can affect BMD levels, and the combined diagnosis of CTRP3, MMP-3, and MMP-9 has certain reference value for osteoporosis.
卢学超1 徐园园1▲ 魏迎凤1 任亚丽2 王霞3. C1q/TNF相关蛋白3、基质金属蛋白酶3和基质金属蛋白酶9对绝经后女性骨密度的影响[J]. 中国医药导报, 2023, 20(33): 109-112.
LU Xuechao1 XU Yuanyuan1▲ WEI Yingfeng1 REN Yali2 WANG Xia3. Effects of C1q/TNF-related protein 3, matrix metalloproteinase 3, and matrix metalloproteinase 9 on bone mineral density in postmenopausal women. 中国医药导报, 2023, 20(33): 109-112.
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2023, Vol. 20 
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