Abstract：Objective To explore the application effect of mechanical thrombectomy (MT) and intra-arterial thrombolysis (IAT) in patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction admitted to Suqian Hospital Affiliated to Xuzhou Medical University from January 2021 to July 2022 were included in the study and they were divided into thrombectomy group and thrombolysis group according to different treatment methods, with 60 cases in each group. The thrombectomy group received MT and the thrombolysis group received IAT. The clinical efficacy of the two groups was recorded and compared, the vascular recirculation condition of the two groups was compared, and the levels of neurological function indicators (National Institutes of Health stroke scale [NIHSS] score, neuron specific enolase [NSE], S100β protein [S100β], brain-derived neurotrophic factor [BDNF]) before and after surgery of the two groups were measured and compared. Complications and prognosis of the two groups were recorded and compared. Results The clinical effect of thrombectomy group was better than that of thrombolysis group, and the difference was statistically significant (P＜0.05). The vascular condition of thrombectomy group was better than that of thrombolysis group, and the difference was statistically significant (P＜0.05). One week after surgery, the NIHSS score, NSE, and S100β levels of the two groups were decreased, while the BDNF level was increased, and the NIHSS score, NSE, and S100β levels of the thrombectomy group were lower than those of the thrombolysis group, while the BDNF level of the thromectomy group was higher than that of the thrombolysis group, and the differences were statistically significant (P＜0.05). The incidence of complications and mortality in thrombectomy group were lower than those in thrombolysis group, and the differences were statistically significant (P＜0.05). Conclusion The therapeutic effect of MT on patients with acute cerebral infarction is significantly better than that of IAT, which can effectively help vascular recanalization, improve postoperative neurological function of patients, and reduce complications and mortality.
王黎明 杨丹丹 陈静 蔡丹丹 张雪玲▲. 机械取栓与动脉内溶栓在急性脑梗死患者中的应用效果比较[J]. 中国医药导报, 2023, 20(32): 98-101.
WANG Liming YANG Dandan CHEN Jing CAI Dandan ZHANG Xueling▲. Comparison of application effect of mechanical thrombectomy and intra-arterial thrombolysis in patients with acute cerebral infarction. 中国医药导报, 2023, 20(32): 98-101.
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