Abstract：Jadomycin and its derivatives are a new group of anthracycline antibiotics isolated from Streptomyces venezuelans, and have been receiving increasing attention because of their cytotoxicity to a variety of cancers, especially breast cancer. This article reviews the research progress of Jadomycin and its derivatives in relation to breast cancer. This review is divided into two parts, the first summaries the anti-breast cancer effect of Jadomycin and its derivatives; the second provides an overview of anti-breast cancer mechanisms of Jadomycin and its derivatives, including induced apoptosis, copper dependent reactive oxygen species generation, topoisomerase inhibition, and aurora kinase B inhibition, etc., which provided an overview of a potential new chemotherapy drug for clinicians.
马澜婧 谈元郡 朱志博 张百红. 杰多霉素及衍生物的抗乳腺癌作用及机制研究进展[J]. 中国医药导报, 2023, 20(32): 64-67.
MA Lanjing TAN Yuanjun ZHU Zhibo ZHANG Baihong. Research progress on anti-breast cancer effect and mechanism of Jado-mycin and its derivatives. 中国医药导报, 2023, 20(32): 64-67.
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