Clinical effect of supramolecular salicylic acid on acne rosacea and its influence on inflammatory factors
HAN Yiyang1 HU Hao2 WANG Dan3
1.Department of Dermatology, the Second People’s Hospital of Huaian, Jiangsu Province, Huaian 223001, China; 2.Department of Dermatology, Baoying People’s Hospital, Jiangsu Province, Baoying 225800, China; 3.Department of Dermatology, Siyang Hospital of Traditional Chinese Medicine, Jiangsu Province, Suqian 223700, China
Abstract：Objective To observe the clinical effect of supramolecular salicylic acid on acne rosacea and its influence on inflammatory factors. Methods Eighty-six patients with acne rosacea treated in the Second People’s Hospital of Huaian, Jiangsu Province were selected as the study objects, and were divided into microneedle group (43 cases) and microneedle + salicylic acid group (43 cases) according to random number table method. Both groups were treated with antibiotics, the microneedles group was treated with gold microneedles on the basis of antibiotics, and the microneedles + salicylic acid group was treated with supramolecular salicylic acid on the basis of microneedles group. After continuous treatment for eight weeks, the differences of inflammatory factors, skin physiological function, symptom score, and quality of life between the two groups were compared, and the efficacy and safety of the two groups were analyzed. Results In the microneedle + salicylic acid group, six cases fell off during treatment, and 37 cases were eventually included. After treatment, trans epidermal water loss, skin erythematous index, skin oil, interleukin (IL)-4, IL-6, IL-37, and tumor necrosis fact-α (TNF-α) in two groups were lower than those before treatment, and those of microneedles + salicylic acid group were lower than those of microneedles group, the differences were statistically significant (P＜0.05). After treatment, cuticle water content and acne-specific quality of life questionnaire scores in two groups were higher than those before treatment, and those of microneedles + salicylic acid group were higher than those of microneedles group, the differences were statistically significant (P＜0.05). After treatment, the scores of flushing, erythema, papule, pustules, and telangiectasia in two groups were lower than those before treatment, and those of microneedle + salicylic acid group were lower than those of microneedle group, the differences were statistically significant (P＜0.05). The therapeutic effect of microneedle + salicylic acid group was better than that of microneedle group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Supramolecular salicylic acid and gold microneedles in the treatment of rosacea can improve skin physiological function, inhibit inflammatory response, alleviate symptoms, and improve quality of life.
韩伊杨1 胡浩2 王丹3. 超分子水杨酸外涂治疗玫瑰痤疮的临床效果及对炎症因子的影响[J]. 中国医药导报, 2023, 20(31): 92-96.
HAN Yiyang1 HU Hao2 WANG Dan3. Clinical effect of supramolecular salicylic acid on acne rosacea and its influence on inflammatory factors. 中国医药导报, 2023, 20(31): 92-96.
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2023, Vol. 20 
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