Relationship between MTHFR C677T gene mutation, and the levels of serum Hcy, folic acid, and vitamin B12 with spontaneous abortion in Uygur pregnant women in Kashgar area
Abuduhelili Abudurexiti1 Abulizi Abuduzhayier1 FAN Xixiang2 Buzure Ali3
1.Department of Pharmacy, the First People’s Hospital of Kashi, Xinjiang Uygur Autonomous Region, Kashi 844000, China; 2.the Network Information Center, the First People’s Hospital of Kashi, Xinjiang Uygur Autonomous Region, Kashi 844000, China; 3.Department of Medical Administration, the First People’s Hospital of Kashi, Xinjiang Uygur Autonomous Region, Kashi 844000, China
Abstract：Objective To investigate the relationship between MTHFR C677T gene mutation, and the levels of serum homocysteine (Hcy), folic acid, and vitamin B12 with spontaneous abortion in Uygur pregnant women in Kashgar area. Methods From January 2020 to June 2021, 75 spontaneous abortion patients in the Reproductive Medicine Center of the First People’s Hospital of Kashi, Xinjiang Uygur Autonomous Region (hereinafter referred to as “our hospital”) were selected as the observation group, and 75 healthy pregnant women who underwent physical examination in our hospital during the same period were selected as the control group. The polymorphism of MTHFR C677T locus gene and the levels of serum Hcy, folic acid, and vitamin B12 between two groups were detected; the levels of serum Hcy, folic acid, and vitamin B12 levels among different MTHFR genotypes were compared; the influencing factors of spontaneous abortion among Uyghur pregnant women in Kashgar area were analyzed. Results The proportion of induced abortion history, infection in early pregnancy, and the number of induced abortion in the observation group were higher than those in the control group (P＜0.05). There were significant differences in genotype and allele distribution between the two groups (P＜0.05). The level of serum Hcy in the observation group was higher than that in the control group, and the levels of folic acid and vitamin B12 were lower than those in the control group (P＜0.05). The level of serum Hcy of TT genotype was higher than that of CT and CC genotype, and the levels of folate and vitamin B12 were lower than those of CT and CC genotype (P＜0.05); there were no significant differences in the levels of serum Hcy, folic acid, and vitamin B12 between CT and CC genotype patients (P＞0.05). TT genotype and high Hcy level were risk factors for spontaneous abortion in Uyghur pregnant women in Kashgar area (OR=2.044, 2.010, P＜0.05), and high folic acid and vitamin B12 levels were protective factors for spontaneous abortion in Uyghur pregnant women in Kashgar area (OR=0.587, 0.614, P＜0.05). Conclusion MTHFR C677T genotype, the levels of serum Hcy, folic acid, and vitamin B12 are associated with spontaneous abortion in Uyghur pregnant women in Kashgar area.
阿卜杜合力力·阿布都热西提1 阿布力孜·阿卜杜扎依尔1 范希翔2 布祖热·艾力3. 喀什地区维吾尔族妊娠妇女MTHFR C677T基因突变、血清Hcy、叶酸及维生素B12水平与自然流产的关系[J]. 中国医药导报, 2023, 20(30): 113-116,129.
Abuduhelili Abudurexiti1 Abulizi Abuduzhayier1 FAN Xixiang2 Buzure Ali3. Relationship between MTHFR C677T gene mutation, and the levels of serum Hcy, folic acid, and vitamin B12 with spontaneous abortion in Uygur pregnant women in Kashgar area. 中国医药导报, 2023, 20(30): 113-116,129.
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2023, Vol. 20 
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