A reevaluation on systematic review of chinese medicine injection for the prevention and treatment of chemotherapy-related cardiotoxicity
ZHANG Mengdi1 PU Dongqing1 SHI Guangxi1 LI Jingwei2
1.The First Clinical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China; 2.Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China
Abstract：Objective To evaluate the quality of report, methodological quality, and evidence level of systematic review on the prevention and treatment of chemotherapy-related cardiotoxicity by traditional Chinese medicine injection. Methods The PubMed, EMBase, Cochrane Library, CNKI, VIP, Wanfang Data, China Biomedical Literature Service System database were searched, the time limited to the database establishment until April 31, 2022. The published articles on systematic reviews/meta-analyses of traditional Chinese medicine injection for the prevention and treatment of chemotherapy-related cardiotoxicity were collected. The PRISMA statement was used to evaluate the reporting quality of the included studies, the AMSTAR2 scale and the GRADE rating system were used to evaluate the methodological quality and the level of evidence. Results A total of nine articles were included, and PRISMA scores ranged from 13.5 to 23 points. There were shortcomings in scheme and registration, other analysis and funding sources. AMSTAR2 evaluation indicated that the quality rating of one article was very low, three articles were low, and five articles were intermediate. GRADE Evidence quality was graded from medium quality to very low quality. A total of 49 outcome indicators were included, of which 11 were of medium quality, 10 were of low quality, and 28 were of very low quality. Conclusion The existing evidence suggests that the systematic evaluation methodology and evidence quality of traditional Chinese medicine injection for prevention and treatment of chemotherapy-related cardiotoxicity are low, but the efficacy is positive. Compared with the use of chemotherapy drugs alone or placebo, the incidence of electrocardiogram abnormalities and left ventricular ejection fraction of the main outcome indicators suggest that traditional Chinese medicine injection can effectively improve the prevention and treatment of chemotherapy-related cardiotoxicity.
张梦棣1 浦冬青1 时光喜1 李静蔚2. 中药注射液防治化疗相关心脏毒性的系统评价再评价[J]. 中国医药导报, 2023, 20(29): 144-151.
ZHANG Mengdi1 PU Dongqing1 SHI Guangxi1 LI Jingwei2. A reevaluation on systematic review of chinese medicine injection for the prevention and treatment of chemotherapy-related cardiotoxicity. 中国医药导报, 2023, 20(29): 144-151.
2023, Vol. 20 
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