Abstract：Objective To investigate the influencing factors of cognitive disorder (CD) in elderly patients with oral Warfarin atrial fibrillation (AF). Methods A total of 121 patients with atrial fibrillation admitted to Chengde Central Hospital, Hebei Province from February 2019 to February 2022 were selected in a cross-sectional survey. The patients were divided into group without CD (59 cases) and group with CD (62 cases) by using the cognitive disorder rating scale (CDR). The drug use, medical history, and demographic data were collected. Logistic regression analysis was used to analyze the influencing factors of cognitive impairment, and receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of oral Warfarin in CD. Results There were significant differences in Warfarin anticoagulant stability, hypertension, diabetes, and left ventricular ejection fraction (LVEF) among patients with different CD patients (P＜0.05). Logistic regression analysis showed that hypertension (OR [95%CI] =3.003 [1.184, 7.617]), diabetes (OR [95%CI] =4.347 [1.756, 10.759]), Warfarin anticoagulation (OR [95%CI] =3.915 [1.572, 9.750]), and LVEF (OR [95%CI] =0.893 [0.826, 0.966]) were the influencing factors for CD in elderly patients with AF(P＜0.05). The area under the curve (AUC [95%CI]) of Warfarin anticoagulant treatment was 0.802 (0.725-0.879), and the sensitivity and specificity of CD were 83.9% and 62.7% when the maximum Jorden index was 0.466. Conclusion Diabetes, hypertension, warfarin anticoagulant treatment stability, LVEF are influencing factors for CD in patients with AF, Warfarin anticoagulant treatment stability has a good predictive value for CD in patients with AF.
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2023, Vol. 20 
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