Effect of Zhibai Dihuang Pills combined with Oberning Gel in treating refractory recurrent aphthous ulcer with syndrome of hyperactivity of fire due to yin deficiency in middle-and-old age patients
CHEN Xue1 ZHANG Hailong1 QUAN Xingmiao2 LYU Xin1 HUO Feng1 SU Zhejun1#br#
1.Department of Stomatology, Affiliated Hospital of Chengde Medical University, Hebei Province, Chengde 067000, China;
2.Department of Traditional Chinese Medicine, Affiliated Hospital of Chengde Medical University, Hebei Province, Chengde 067000, China
Abstract：Objective To explore the effect of Zhibai Dihuang Pills combined with Oberning Gel in treating refractory recurrent aphthous ulcer with syndrome of hyperactivity of fire due to yin deficiency in middle-and-old age patients. Methods A total of 47 middle-and-old age patients with refractory recurrent aphthous ulcer with syndrome of hyperactivity of fire due to yin deficiency treated in the Affiliated Hospital of Chengde Medical College from January 2019 to June 2020 were selected. They were divided into control group (Thalidomide + Oberning Gel) in 23 cases and Chinese medicine group (Zhibai Dihuang Pills + Oberning Gel) in 24 cases by random number table method. The treatment course of both groups was four weeks, and the follow-up was once every four weeks after the treatment, for a total of 24 weeks. The local symptom improvement before treatment and after one week of treatment were compared between the two groups, and the therapeutic effect, serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels before treatment and after four weeks of treatment were compared between the two groups. The total time without ulcers and the total number of ulcers recurrences were compared between the two groups during the follow-up period, and the occurrence of adverse reactions was recorded between the two groups. Results After one week of treatment, the number of ulcers, the size of ulcers, and the scores of visual analogue scale in two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After one week of treatment, there were no significant differences in the number of ulcers, size of ulcers, and scores of visual analogue scale between the two groups (P＞0.05). The healing time of ulcer in medicine group was longer than that in Chinese control group, and the difference was statistically significant (P＜0.05). After four weeks of treatment, the levels of TNF-α and IL-6 were lower than those before treatment, and those of Chinese medicine group were lower than those of control group, the differences were statistically significant (P＜0.05). After 24 weeks of follow-up, there was no significant difference in total time without ulcers and the total number of ulcers recurrences between the two groups (P＞0.05). There was no significant difference in efficacy between the two groups (P＞0.05). The total incidence of adverse reactions in Chinese medicine group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Zhibai Dihuang Pills combined with Oberning Gel in the treatment of refractory recurrent aphthous ulcer with syndrome of hyperactivity of fire due to yin deficiency in middle-and-old age patients has a significant effect on the overall recurrence, can reduce the occurrence of ulcers, prolong the interval time, help to reduce the recurrence rate of ulcers, the effect is similar to Thalidomide, and has fewer adverse reactions, worthy of clinical promotion.
陈雪1 张海龙1 权兴苗2 吕鑫1 霍峰1 苏哲君1. 知柏地黄丸联合欧柏宁凝胶剂治疗中老年阴虚火旺型顽固性复发性口腔溃疡的效果[J]. 中国医药导报, 2023, 20(28): 97-100.
CHEN Xue1 ZHANG Hailong1 QUAN Xingmiao2 LYU Xin1 HUO Feng1 SU Zhejun1. Effect of Zhibai Dihuang Pills combined with Oberning Gel in treating refractory recurrent aphthous ulcer with syndrome of hyperactivity of fire due to yin deficiency in middle-and-old age patients. 中国医药导报, 2023, 20(28): 97-100.
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