Exploration of the medication rule for the use of Ding Zhiguo in the treatment of hyperthyroidism based on traditional Chinese medicine inheritance assistance system
GE Yaxue1 CHEN Xiaoheng1 QI Shuo2 LI Zhe1 LI Huilong1 LIU Meijun1 DING Zhiguo2
1.Department of Thyropathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Shaanxi Province, Tongchuan 727100, China
Abstract：Objective To explore the prescription and medication rule of Professor Ding Zhiguo in the treatment of hyperthyroidism with the traditional Chinese medicine inheritance assistance system (V2.5) software. Methods Traditional Chinese medicine prescriptions for the treatment of hyperthyroidism issued by Professor Ding Zhiguo in the thyroidology outpatient Department of Thyropathy Dongzhimen Hospital, Beijing University of Chinese Medicine from July 2019 to November 2020 were collected and a database was established. Frequency statistics, association rules, and so on were used for data mining to analyze and study the core drugs and their nature, flavour, channel tropism, and prescription formation laws. Results A total of 197 prescriptions meeting the criteria were screened out, involving 84 kinds of traditional Chinese medicine, and 22 drugs with frequency ≥110 in the prescriptions. The main channel tropism of drugs were liver and lung channels. The nature and flavour of drugs were bitter and cold respectively. There were 33 couplet medicines with frequency ≥180 and 19 groups of three medicines with frequency ≥185. There were six core prescriptions, six new formula core combinations, and three new prescriptions. The core prescriptions were: Prunellae Spica, Albiziae Flos, Ranunculi Ternati Radix, Bupleuri Radix, Cyperi Rhizoma, Os Draconis, Ostreae Concha, Scutellariae Radix, Platycodonis Radix, Moutan Cortex, Polygoni Multiflori Caulis, Anemarrhenae Rhizoma, Gypsum Fibrosum, Astragali Radix, Paeoniae Radix Rubra, Salviae Miltiorrhizae Radix Et Rhizoma, Taraxaci Herba, Belamcandae Rhizoma, Alismatis Rhizoma, Paeoniae Radix Alba, Margaritifera Concha, Ziziphi Spinosae Semen. Conclusion Professor Ding Zhiguo’s treatment of hyperthyroidism is based on the theory of “Yeben Xiangying”. He is good at using bitter and cold drug to improve the warm-heat disease caused by hyperthyroidism, combined with sweet drug to regulate and tonify qi, blood, yin and yang, sooth liver and strengthen spleen, regulate liver and lung, and treat both symptoms and root causes.
葛亚雪1 陈晓珩1 祁烁2 李哲1 李会龙1 刘美君1 丁治国2. 基于中医传承辅助系统探讨丁治国教授治疗甲状腺功能亢进症的用药规律[J]. 中国医药导报, 2023, 20(28): 20-25.
GE Yaxue1 CHEN Xiaoheng1 QI Shuo2 LI Zhe1 LI Huilong1 LIU Meijun1 DING Zhiguo2. Exploration of the medication rule for the use of Ding Zhiguo in the treatment of hyperthyroidism based on traditional Chinese medicine inheritance assistance system. 中国医药导报, 2023, 20(28): 20-25.
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