Abstract：Objective To observe the application of early cognitive language rehabilitation training combined with repetitive transcranial magnetic stimulation (rTMS) in children with global developmental delay (GDD). Methods A prospective randomized controlled trial was used, 64 children newly diagnosed with GDD in Hebei Children’s Hospital from January 2021 to March 2022 were selected as study objects. They were divided into the experimental group and the control group according to the random number table method, with 32 cases in each group. The control group used early cognitive language rehabilitation training intervention, and the experimental group was combined with rTMS intervention on the basis of the control group, the intervention lasted nine months. The intelligence level, neuropsychobehavioral development, motor function, and muscle tension of the two groups were compared before and after intervention. Results During intervention, four cases were excluded, and two cases were lost to follow-up in the control group; in the experimental group, one case was transferred to hospital for treatment and one case was lost to follow-up; finally, 30 patients in both groups were followed up. After intervention, the verbal intelligence quotient, performance intelligence quotient, and full intelligence quotinent scores of the two groups were higher than those before intervention, and the experimental group was higher than the control group (P＜0.05). After intervention, the scores of adaptive developer and gross motor function measure-88 in the two groups were higher than those before intervention, and those in the experimental group were higher than those in the control group (P＜0.05). After intervention, the muscle tension of the two groups was better than that before intervention, and the experimental group was better than the control group (P＜0.05). Conclusion Early cognitive language rehabilitation training combined with rTMS intervention can significantly improve the intelligence level of children with GDD, and can also improve muscle tone, thereby improving motor function.
陈玲 岳玲 刘倩倩 王泽熙 贾蓉 张浩天 吴召轩. 早期认知语言康复训练联合rTMS在全面性发育迟缓患儿康复中的应用[J]. 中国医药导报, 2023, 20(27): 104-107,142.
CHEN Ling YUE Ling LIU Qianqian WANG Zexi JIA Rong ZHANG Haotian WU Zhaoxuan. Application of early cognitive language rehabilitation training combined with rTMS in rehabilitation of children with global developmental delay. 中国医药导报, 2023, 20(27): 104-107,142.
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