Research progress on correlation between aldehyde dehydrogenase 2 gene polymorphism and the efficacy of nitroglycerin in patients with stable angina pectoris
GAO Bizhen YU Jiangli DONG Xiao
Cardiovascular Disease Diagnosis and Treatment Center, Affiliated Hospital of Hubei University of Medicine Taihe Hospital of Shiyan, Hubei Province, Shiyan 442000, China
Abstract：Mitochondrial acetaldehyde dehydrogenase 2 (ALDH2) has multiple gene polymorphism loci, the most common mutation loci is rs671, which is associated with the incidence and severity of coronary artery disease. ALDH2 gene mutation can lead to a significant decrease in its enzyme activity, and angina pectoris patients with ALDH2 gene mutation are more likely to develop tolerance during nitroglycerin administration. Therefore, the relationship between ALDH2 gene mutation and nitroglycerin tolerance is the focus of current research, and the development of ALDH2 enzyme activity activators may become a new treatment method to improve nitroglycerin tolerance. This article reviews the correlation between ALDH2 gene polymorphisms and the efficacy of nitroglycerin in patients with coronary heart disease, in order to provide a new idea and basis for clinical treatment of stable angina pectoris of coronary heart disease.
高必贞 余将丽 董晓. 乙醛脱氢酶2基因多态性与稳定型心绞痛患者硝酸甘油疗效的相关性研究进展[J]. 中国医药导报, 2023, 20(27): 43-46.
GAO Bizhen YU Jiangli DONG Xiao. Research progress on correlation between aldehyde dehydrogenase 2 gene polymorphism and the efficacy of nitroglycerin in patients with stable angina pectoris. 中国医药导报, 2023, 20(27): 43-46.
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