1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Cadre Health Care, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Abstract：Objective To investigate the medication rule of Professor Feng Ling in the treatment of chronic heart failure. Methods Effective chronic heart failure medical records of Professor Feng Ling’s outpatient department in Guang’anmen Hospital, China Academy of Chinese Medical Sciences from January 2016 to January 2022 were collected. Traditional Chinese medicine inheritance computing platform (V3.0) was used to conduct drug frequency, four nature, five flavours, channel tropism, efficacy, and association rules of prescriptions, and to explore medication rules. Using the “prescription cluster analysis” module, the core prescription was mined by the entropy hierarchical clustering method of complex system. Results A total of 1 151 effective prescriptions were collected, involving 225 kinds of Chinese materia medica. There were ten kinds of Chinese materia medica with frequency≥467, among which Astragali Radix, Santali Albi Lignum, and Mori Cortex had the highest frequency. In the four nature, cold and warm were the main, followed by flat. In the five flavours, sweet and pungent were the main, followed by bitter. In the channel tropism, spleen, lung, and heart channels were the main. The efficacy of the drug was divided into 17 categories, such as regulating qi, tonifying deficiency, diuresis and diffusing dampness, promoting blood circulation for removing blood stasis, resolving phlegm and relieving cough and asthma, and so on. Association rule analysis obtained 18 associated couplet medicines. Eight core prescription were obtained by high-frequency drug cluster analysis. The core presicripton were composed of Astragali Radix, Mori Cortex, Arecae Pericarpium, Poria, Polyporus, Salviae Miltiorrhizae Radix Et Rhizoma, Santali Albi Lignum, and Aucklandiae Radix. Conclusion Professor Feng Ling’s medication approach for chronic heart failure involves treating qi deficiency, blood stasis, and water stasis as the core pathogenesis. The treatment of invigorating spleen and benefiting qi, activating blood circulation to dissipate blood stasis, inducing diuresis for removing edema as the method. “Spleen, lung and heart” are treated simultaneously; “sweet, pungent, and bitter” are used all at once.
李思明1 程晓振2 陈兴娟2 侯承志2 吴怡茹2 冯玲2. 基于数据挖掘探讨冯玲教授治疗慢性心力衰竭用药规律[J]. 中国医药导报, 2023, 20(27): 25-29.
LI Siming1 CHENG Xiaozhen2 CHEN Xingjuan2 HOU Chengzhi2 WU Yiru2 FENG Ling2. Discussion on the medication rule of Professor Feng Ling in treating chronic heart failure based on data mining. 中国医药导报, 2023, 20(27): 25-29.
京公网安备 11010502046598号