Research progress in the application of metabolic glutamate receptor 5 positron emission tomography in neuropsychiatric diseases
ZHANG Linyue1 HUANG Qi2 HUA Fengchun1▲#br#
1.Department of Nuclear Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
2.PET Center, Huashan Hospital Affiliated to Fudan University, Shanghai 200032, China
Abstract：Metabolic glutamate receptors 5 (mGluR5) play an important role in neuropsychiatric diseases, positron emission tomography (PET) can noninvitatively assess mGluR5 changes in nervous system diseases at the in vivo molecular level. In order to further explore the changes and pathological mechanism of mGluR5 in neuropsychiatric diseases, this paper reviews the molecular mechanism of mGluR5 and the application of PET in Alzheimer’s disease, Parkinson disease, epilepsy, mental diseases, and sleep and arousal, etc., in order to provide guidance for the experimental research and clinical application of mGluR5 imaging.
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