Abstract：In recent years, more and more studies have been conducted on the application of hyperoxia in tumor therapy. Hyperoxic therapy can play an antitumor role by alleviating tumor hypoxia and affecting complex biological responses. At the same time, hyperoxia improves the effectiveness of existing therapies, such as radiotherapy, chemotherapy, and immunotherapy. This article summarizes and discusses the internal mechanism of hyperoxia therapy against tumor, reviewed the auxiliary function of hyperoxia therapy as existing tumor treatment, and reveals the anti-tumor effect of hyperoxia therapy and the potential of hyperoxia as an auxiliary therapy for tumor, and provides a new strategy for the application of hyperoxia in the treatment of tumor.
庄严 江春平 吴俊华. 高氧疗法在恶性肿瘤患者治疗中应用的研究进展[J]. 中国医药导报, 2023, 20(25): 51-53.
ZHUANG Yan JIANG Chunping WU Junhua. Research progress on the application of hyperoxia therapy in the treatment of patients with malignant tumors. 中国医药导报, 2023, 20(25): 51-53.
[1] Hochberg CH，Semler MW，Brower RG. Oxygen Toxicity in Critically Ill Adults [J]. Am J Respir Crit Care Med，2021， 204（6）：632-641.
[2] Li K，Gong Y，Qiu D，et al. Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC [J]. J Immunother Cancer，2022，10（8）： e004006.
[3] Schottlender N，Gottfried I，Ashery U. Hyperbaric Oxygen Treatment：Effects on Mitochondrial Function and Oxidative Stress [J]. Biomolecules，2021，11（12）：1827.
[4] Herrera-Campos AB，Zamudio-Martinez E，Delgado-Bellido D，et al. Implications of Hyperoxia over the Tumor Microenvironment：An Overview Highlighting the Importance of the Immune System [J]. Cancers（Basel），2022，14（11）：2740.
[5] O'connor JPB，Robinson SP，Waterton JC. Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI [J]. Br J Radiol，2019，92（1095）：20180642.
[6] Zhang S，Li Z，Wang Q，et al. NIR-Ⅱ photothermally triggered“oxygen bomb”for hypoxic tumor programmed cascade therapy [J]. Adv Mater，2022：e2201978.
[7] Wang D，Wu H，Lim W Q，et al. A Mesoporous Nanoenzyme Derived from Metal-Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy [J]. Adv Mater，2019， 31（27）：e1901893.
[8] Petrakis G，Mantso T，Koukourakis MI，et al. Effectiveness of Hyperthermia as Monotherapy and Adjuvant Therapy Approaches Against an In Vitro Model of Colorectal Carcinoma [J]. Anticancer Res，2022，42（5）：2363-2374.
[9] Davis FM. Acute central nervous system oxygen toxicity at normobaric pressure [J]. Diving Hyperb Med，2021，51（1）：125.
[10] Wang P，Gong S，Pan J，et al. Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2 [J]. Cell Death Discov，2021，7（1）：103.
[11] De Bels D，Tillmans F，Corazza F，et al. Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines [J]. Biomolecules，2020，10（2）：282.
[12] Seledtsov VI，Von Delwig AA. Oxygen therapy in traditional and immunotherapeutic treatment protocols of cancer patients：current reality and future prospects [J]. Expert Rev Anticancer Ther，2022，22（6）：575-581.
[13] Sidramagowda Patil S，Soundararajan R，Fukumoto J，et al. Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia [J]. Front Pharmacol，2022，13：762840.
[14] Dong W，Zhu X，Liu X，et al. Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury [J]. Free Radic Biol Med，2021，173：142-150.
[15] Arienti C，Pignatta S，Zanoni M，et al. High-pressure oxygen rewires glucose metabolism of patient-derived glioblastoma cells and fuels inflammasome response [J]. Cancer Lett，2021，506：152-166.
[16] Li YC，Chen CH，Chang CL，et al. Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms [J]. Int J Biol Sci，2021，17（14）：3728-3744.
[17] Liu X，Qin H，Li Z，et al. Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway [J]. Eur Respir J，2022， 60（6）：2200062.
[18] Kohshi K，Kinoshita Y，Imada H，et al. Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas [J]. Br J Cancer，1999，80（1/2）：236-241.
[19] Meier EL，Hummelink S，Lansdorp N，et al. Perioperative hyperbaric oxygen treatment and postoperative complications following secondary breast reconstruction after radiotherapy：a case-control study of 45 patients [J]. Diving Hyperb Med，2021，51（3）：288-294.
[20] Md JBM，Md EZ，Md MAF，et al. Overview and Emerging Trends in the Treatment of Osteoradionecrosis [J]. Curr Treat Options Oncol，2021，22（12）：115.
[21] Forner LE，Dieleman FJ，Shaw RJ，et al. Hyperbaric oxygen treatment of mandibular osteoradionecrosis：Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1 [J]. Radiother Oncol，2022，166：137-144.
[22] Zhao D，Tao W，Li S，et al. Apoptotic body-mediated intercellular delivery for enhanced drug penetration and whole tumor destruction [J]. Sci Adv，2021，7（16）： eabg0880.
[23] Qiao J，Chen L，Huang X，et al. Effects of nebulized N-- acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia--induced lung injury [J]. J Cell Phy- siol，2019，234（7）：10547-10553.
[24] Zembrzuska K，Ostrowski RP，Matyja E. Hyperbaric oxygen increases glioma cell sensitivity to antitumor treatment with a novel isothiourea derivative in vitro [J]. Oncol Rep，2019， 41（5）：2703-2716.
[25] Rabender CS，Bruno N，Alam A，et al. Sepiapterin Enhances Tumor Radio- and Chemosensitivities by Promoting Vascular Normalization [J]. J Pharmacol Exp Ther，2018，365（3）：536-543.
[26] Lee HY，Kim IK，Lee HI，et al. Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer [J]. Korean J Intern Med，2018，33（3）：541-551.
[27] Im J，Kwon HY，Kim IK，et al. Normobaric hyperoxia re-sensitizes paclitaxel-resistant lung cancer cells [J]. Mol Cell Toxicol，2022，18（4）：539-548.
[28] Hatfield SM，Sitkovsky MV. Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy [J]. J Clin Invest，2020，130（11）：5629-5637.
[29] Janigian YY，Kawazoe A，Ya?觡ez P，et al. The KEYNOTE- 811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer [J]. Nature，2021，600（7890）：727-730.
[30] Qian X，Zhang Q，Shao N，et al. Respiratory hyperoxia reverses immunosuppression by regulating myeloid-derived suppressor cells and PD-L1 expression in a triple-negative breast cancer mouse model [J]. Am J Cancer Res，2019，9（3）：529-545.
[31] Liu X，Ye N，Liu S，et al. Hyperbaric Oxygen Boosts PD-1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors [J]. Adv Sci（Weinh），2021，8（15）：e2100233.
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