Abstract：Leucine-rich-α-2-glycoprotein 1 (LRG1) is one of the highly conserved member of the leucine-rich repeat protein family. Recent studies have found that LRG1 is a novel adipokine, which is closely related to glycolipid metabolism. In terms of glucose metabolism, LRG1 gene knockout can improve insulin resistance induced by high fat feeding, and LRG1 can inhibit insulin signaling and promote liver gluconeogenesis. In terms of lipid metabolism, LRG1 gene knockout can inhibit lipid synthesis and reduce serum triglyceride and cholesterol levels. In addition, the levels of LRG1 in obese people and obese mice are significantly higher, and the level of LRG1 is significantly correlated with a variety of diabetes complications, suggesting that LRG1 may be a risk factor for obesity and diabetes vascular complications. This article reviews the research progress of LRG1 in glycolipid metabolism and related diseases, in order to provide a new direction for the prediction and treatment of glycolipid metabolism related diseases.
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