中医药调控相关信号通路防治心室重构的研究进展

doi:10.20047/j.issn1673-7210.2023.25.07

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摘要心室重构（VR）是一种复杂的病理过程，是导致心力衰竭发病率和死亡率上升的关键因素，其发生机制涉及多种细胞因子参与信号调节。中医药防治VR与TGF-β/Smad、NF-κB、MAPK、NLRP3炎症小体、PI3K/Akt/ mTOR、Ca2+和VEGF/VEGFR2等信号通路的调控密切相关。本文就VR的病理变化和中药单体与复方调控相关信号通路防治VR的机制进行综述，阐明调控相关信号通路干预VR治疗心力衰竭具有积极作用，旨在为临床防治VR提供参考。

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	徐存1　　王保和2

关键词 ：中医药, 心室重构, 信号通路, 研究进展

Abstract：Ventricular remodeling (VR) is a complex pathological process, which is a key factor leading to increased morbidity and mortality of heart failure, and its mechanism involves a variety of cytokines involved in signal regulation. The prevention and treatment of VR by traditional Chinese medicine is closely related to the regulation of TGF-β/Smad, NF-κB, MAPK, NLRP3 inflammatome, PI3K/Akt/mTOR, Ca2+, and VEGF/VEGFR2 signaling pathways. In this paper, the pathological changes of VR and the mechanism of Chinese medicine monomer and compound regulation related signal pathway to prevent and treatment VR were reviewed, and the regulation related signal pathway intervention in VR treatment of heart failure has a positive effect, aiming to provide a reference for clinical prevention and treatment of VR.

Key words： Traditional Chinese medicine Ventricular remodeling Signaling pathway Research progress

基金资助:国家科技重大专项-重大新药创制（2018ZX 09734-002）。

通讯作者: 王保和（1964.7-），男，博士，教授，主任医师，博士生导师；研究方向：中医药治疗心脑血管疾病、中药临床药理、临床评价。

作者简介: 徐存（1995.7-），男，天津中医药大学研究生院2020级中医内科学专业在读硕士研究生；研究方向：中医药防治心血管疾病研究。

引用本文:

徐存1　　王保和2. 中医药调控相关信号通路防治心室重构的研究进展[J]. 中国医药导报, 2023, 20(25): 43-46.
XU Cun1 WANG Baohe2. Research progress on prevention and treatment of ventricular remodeling by regulating relevant signaling pathways with traditional Chinese medi- cine. 中国医药导报, 2023, 20(25): 43-46.

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