Abstract：Objective To study the predictive value of serum microRNA(miR)-126 and miR-138 levels in children with Mycoplasma pneumoniae pneumonia (MPP). Methods A total of 114 children with MPP from July 2020 to October 2022 in Department of Pediatrics, Nantong First People’s Hospital, Jiangsu Province were selected, and they were divided into good prognosis and poor prognosis according to the prognosis condition. The general data and clinical data including gender, age, fever time, severity of illness, blood routine indicators (white blood cell count [WBC], platelet count [PLT], erythrocyte sedimentation rate [ESR]), inflammatory factor indicators (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]), and miR-126 and miR-138 were compared between two groups; the prognostic influencing factors of MPP children and the predictive value of miR-126 and miR-138 levels were analyzed. Results Among 114 children with MPP, 19 had poor prognosis after one course of treatment. The proportion of severe disease and the levels of WBC, PLT, IL-6, TNF-α, CRP, miR-126, and miR-138 in poor prognosis group were higher than those in good prognosis group (P＜0.05); there were no significant differences in gender, age, fever time, and ESR between two groups (P＞0.05). Severity of disease and the levels of WBC, TNF-α, CRP, miR-126, and miR-138 were the influencing factors for poor prognosis of MPP children (OR＞1, P＜0.05). The area under the curve of miR-126 and miR-138 levels predicted the prognosis of MPP children was higher than that detected by each indicator alone. Conclusion Serum miR-126 combined with miR-138 levels have a high prognostic value in MPP children.
葛雯雯 徐婷 宋磊▲. 肺炎支原体肺炎患儿血清miR-126联合miR-138水平对预后的预测价值[J]. 中国医药导报, 2023, 20(24): 101-104.
GE Wenwen XU Ting SONG Lei▲. Predictive value of serum miR-126 and miR-138 levels in children with Mycoplasma pneumoniae pneumonia. 中国医药导报, 2023, 20(24): 101-104.
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