脂肪蓄积指数与动脉粥样硬化性心血管疾病风险水平的相关性研究

doi:10.20047/j.issn1673-7210.2023.23.16

摘要
图/表
参考文献(25)
相关文章 (0)

全文: PDF (567 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨脂肪蓄积指数（LAP）和动脉粥样硬化性心血管疾病（ASCVD）风险水平的相关性。方法选取于2021年6月至2022年4月在湖北医药学院附属国药东风总医院体检的2 266名东风汽车有限公司在职员工，根据10年内ASCVD发生风险水平将其分为低危组（1 334名）、中危组（434名）及高危组（498名）。收集并比较三组临床资料、实验室生化指标及LAP的差异，分析LAP与其他临床指标的相关性，并进一步分析其与10年内ASCVD风险水平的相关性。结果三组性别、吸烟、饮酒、高血压、代谢综合征分布及年龄、收缩压、舒张压、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、体重指数、臀围、肌酐、空腹血糖、LAP、白细胞计数水平比较，差异有统计学意义（P＜0.05）。LAP与性别、年龄、收缩压、舒张压、吸烟、饮酒、总胆固醇、低密度脂蛋白胆固醇、高血压、体重指数、臀围、肌酐、空腹血糖及白细胞计数呈正相关（rs＞0，P＜0.05），与高密度脂蛋白胆固醇呈负相关（rs＜0，P＜0.05）。多因素分析结果显示，校正混杂因素后，LAP是10年内ASCVD风险水平的独立影响因素（P＜0.05）。线性趋势检验显示，LAP分级（L1：≤14.88；L2：＞14.88～26.58；L3：＞26.58～44.90；L4：LAP＞44.90）与10年内ASCVD风险水平具有线性关系（P＜0.05），且为正相关（r＞0，P＜0.05）。结论 LAP是10年内ASCVD发生风险水平的独立危险因素，并与其呈线性关系，临床应予以关注。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	刘桐桐1　　钱航2　　李云鹏2　　邬闻文3　　闵新文2　　杨汉东2　　陈俊2　　李东锋2

关键词 ：动脉粥样硬化心血管疾病, 脂肪蓄积指数, 多元logistic回归模型, 线性趋势检验

Abstract：Objective To investigate the correlation between lipid accumulation product (LAP) and the risk levels of atherosclerotic cardiovascular disease (ASCVD). Methods A total of 2 266 workers of Dongfeng Motor Co., Ltd. who underwent physical examination in Dongfeng General Hospital Affiliated to Hubei University of Medicine from June 2021 to April 2022 were selected and divided into low risk group (1 334 workers), medium risk group (434 workers), and high risk group (498 workers) according to the risk level of ASCVD within ten years. Clinical data, laboratory biochemical indicators, and the differences of LAP among the three groups were collected and compared, and the correlation between LAP and other clinical indicators was analyzed, and the correlation between LAP and the risk levels of ASCVD within ten years was further analyzed. Results The distribution of gender, smoking, drinking, hypertension, metabolic syndrome and levels of age, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, body mass index, hip circumference, creatinine, fasting blood glucose, LAP, and white blood cell count among the three groups were compared, and the differences were statistically significant(P＜0.05). LAP was positively correlated with gender, age, systolic blood pressure, diastolic blood pressure, smoking, drinking, total cholesterol, low density lipoprotein-cholesterol, hypertension, body mass index, hip circumference, creatinine, fasting blood glucose, and white blood cells (rs＞0, P＜0.05), and negatively correlated with high density lipoprotein-cholesterol (rs＜0, P＜0.05). The results of multifactor analysis showed that LAP was an independent factor influencing the risk level of ASCVD within ten years after adjusting for confounding factors (P＜0.05). Linear trend test showed that LAP classification (L1: ≤14.88; L2:＞14.88-26.58; L3:＞26.58-44.90; L4: ＞44.90) had a linear relationship with risk level of ASCVD (P＜0.05), and a positive correlation (r＞0, P＜0.05). Conclusion LAP is an independent risk factor for the risk levels of ASCVD within ten years and has a linear relationship with it, so clinical attention should be paid to it.

Key words： Atherosclerotic cardiovascular disease Lipid accumulation product Multiple logistic regression model Linear trend test

基金资助:国家自然科学基金面上项目（81573244）；
湖北省自然科学基金面上项目（2022CFB453）；
湖北省十堰市科学技术局引导性科研项目（21Y86）；
国药东风总医院院内项目（2022Q01）。

通讯作者: 李东锋（1971.10-），男，硕士，主任医师，硕士生导师；研究方向：心血管流行病学。

作者简介: 刘桐桐（1995.3-），女，锦州医科大学2020级心血管内科专业在读硕士研究生；研究方向：心血管流行病学。

引用本文:

刘桐桐1　　钱航2　　李云鹏2　　邬闻文3　　闵新文2　　杨汉东2　　陈俊2　　李东锋2. 脂肪蓄积指数与动脉粥样硬化性心血管疾病风险水平的相关性研究[J]. 中国医药导报, 2023, 20(23): 77-80.
LIU Tongtong1 QIAN Hang2 LI Yunpeng2 WU Wenwen3 MIN Xinwen2 YANG Handong2 CHEN Jun2 LI Dongfeng2. Study on the correlation between lipid accumulation product and risk levels of atherosclerotic cardiovascular disease. 中国医药导报, 2023, 20(23): 77-80.

链接本文:

https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.23.16 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I23/77

[1] Zibaeenejad F，Mohammadi SS，Sayadi M，et al. Ten-year atherosclerosis cardiovascular disease（ASCVD）risk score and its components among an Iranian population：a cohort-based cross-sectional study [J]. BMC Cardiovasc Disord，2022，22（1）：1-8.
[2] Association AD. Cardiovascular disease and risk management [J]. Diabetes Care，2016，39（Suppl 1）：S60-S71.
[3] Kahn HS. The“lipid accumulation product”performs better than the body mass index for recognizing cardiovascular risk：a population-based comparison [J]. BMC Cardiovasc Disord，2005，5：26.
[4] Du T，Yuan G，Zhang M，et al. Clinical usefulness of lipid ratios，visceral adiposity indicators，and the triglycerides and glucose index as risk markers of insulin resistance [J]. Cardiovasc Diabetol，2014，13：146.
[5] Wang Q，Guo Q，Zhou L，et al. Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events：The Dongfeng-Tongji Cohort Study [J]. J Atheroscler Thromb，2022，29（7）：1040-1058.
[6] 诸骏仁，高润霖，赵水平，等.中国成人血脂异常防治指南（2016年修订版）[J].中国循环杂志，2016，31（10）：937- 953.
[7] Doran AC. Inflammation Resolution：Implications for Athero- sclerosis [J]. Circ Res，2022，130（1）：130-148.
[8] Nayor M，Brown KJ，Vasan RS. The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk [J]. Circ Res，2021，128（2）：287-303.
[9] Wada S，Koga M，Toyoda K，et al. Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia：The J-STARS Echo Study [J]. J Atheroscler Thromb，2018，25（4）：359-373.
[10] Schipper HS，de Ferranti S. Atherosclerotic Cardiovascular Risk as an Emerging Priority in Pediatrics [J]. Pediatrics，2022，150（5）：e2022057956.
[11] Jian S，Yingying Z，Sumei N，et al. The effect of lipid accumulation product and its interaction with other factors on hypertension risk in Chinese Han population：A cross-sectional study [J]. PLoS One，2018，13（6）：e198105.
[12] 刘晨，张黎军.新型体脂指数脂质蓄积指数和内脏脂肪指数的相关研究进展[J].中国糖尿病杂志，2016，24（11）：1032-1035.
[13] Kalisz M，Chmielowska M，MArtyńska L，et al. All-trans- retinoic acid ameliorates atherosclerosis，promotes perivascular adipose tissue browning，and increases adiponectin production in Apo-E mice [J]. Sci Rep，2021，11（1）：4451.
[14] Qiao T，Luo T，Pei H，et al. Association between abdominal obesity indices and risk of cardiovascular events in Chinese populations with type 2 diabetes：a prospective cohort study [J]. Cardiovasc Diabetol，2022，21（1）：225.
[15] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2017年版）[J].中国实用内科杂志，2018，38（4）：292- 344.
[16] Powell-Wiley TM，Poirier P，Burke LE，et al. Obesity and Cardiovascular Disease：A Scientific Statement From the American Heart Association [J]. Circulation，2021，143（21）： e984-e1010.
[17] Spite M，Clària J，Serhan CN. Resolvins，specialized proresolving lipid mediators，and their potential roles in metabolic diseases [J]. Cell Metab，2014，19（1）：21-36.
[18] 李霄鹤，赵晨静，李莲，等.血管内皮细胞在器官纤维化发病机制中作用的研究进展[J].临床内科杂志，2022， 39（10）：663-666.
[19] 中华医学会心血管病学分会，中国康复医学会心脏预防与康复专业委员会，中国老年学和老年医学会心脏专业委员会，等.中国心血管病一级预防指南[J].中华心血管病杂志，2020（12）：1000-1038.
[20] Kyrou I，Panagiotakos DB，Kouli GM，et al. Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults：The ATTICA study [J]. Atherosclerosis，2018，279：10-16.
[21] 段绍杰，刘尊敬，陈佳良，等.脂质蓄积指数、内脏脂肪指数对非酒精性脂肪性肝病的预测价值[J].临床肝胆病杂志，2022，38（01）：129-134.
[22] 张丽，赵珈艺，范乐，等.内脏脂肪指数、脂质蓄积指数与脑卒中高危人群颈动脉粥样硬化的相关性研究[J].中国动脉硬化杂志，2021，29（3）：240-246.
[23] Nusrianto R，Tahapary DL，Soewondo P. Visceral adiposity index as a predictor for type 2 diabetes mellitus in Asian population：A systematic review [J]. Diabetes Metab Synd，2019，13（2）：1231-1235.
[24] Matheson MB，Kato Y，Baba S，et al. Cardiovascular Risk Prediction Using Machine Learning in a Large Japanese Cohort [J]. Circ Rep，2022，4（12）：595-603.
[25] 于娜，朱惠娟.肥胖症的现代内科治疗[J].临床内科杂志，2020，37（9）：619-623.