Research progress of enterovirus infection in neonatal central nervous system
JIN Fang1 XIA Shiwen2#br#
1.School of Medicine, Wuhan University of Science and Technology, Hubei Province, Wuhan 430065, China;
2.Department of Neonatology, Hubei Maternal and Child Health Hospital, Hubei Province, Wuhan 430070, China
Abstract：Enterovirus infection in neonatal central nervous system can be manifested as viral meningitis, encephalitis, or acute flaccid myelitis, and may be complicated by brain damage such as periventricular leukomalacia. In severe cases, it may lead to sequelae such as cognitive impairment and cerebral palsy. Enteroviruses bind to specific receptors under the action of host factors, and destroy the virus clearance and inflammatory response of the body’s immune system through immune escape mechanism. Reverse transcription-polymerase chain reaction is the gold standard for the diagnosis of enterovirus infection in the central nervous system, and clinical treatment mainly focuses on symptomatic support. This article reviews the epidemiology of enterovirus and the pathogenesis, clinical manifestations, early recognition, clinical diagnosis, prevention, treatment of enterovirus infection inneonatal central nervous system, in order to improve the understanding of the disease in the clinic.
金芳1 夏世文2. 新生儿中枢神经系统肠道病毒感染的研究进展[J]. 中国医药导报, 2023, 20(23): 47-51.
JIN Fang1 XIA Shiwen2. Research progress of enterovirus infection in neonatal central nervous system. 中国医药导报, 2023, 20(23): 47-51.
[1] Moghadam AG，Yousefi E，Ghatie MA，et al. Investigating the etiologic agents of aseptic meningitis outbreak in Iranian children [J]. J Family Med Prim Care，2020，9（3）：1573-1577.
[2] 邵肖梅，叶鸿瑁，丘小汕.实用新生儿学[M].5版.北京：人民卫生出版社，2019：494-496.
[3] Bucci S，Coltella L，Martini L，et al. Clinical and Neurodevelopmental Characteristics of Enterovirus and Parechovirus Meningitis in Neonates [J]. Front Pediatr，2022，10：881516.
[4] Brouwer L，Moreni G，Wolthers KC，et al. World-Wide Prevalence and Genotype Distribution of Enteroviruses [J]. Viruses，2021，13（3）：434.
[5] Chuang YY，Huang YC. Enteroviral infection in neonates [J]. J Microbiol Immunol Infect，2019，52（6）：851-857.
[6] 门光国，吕勤.新生儿肠道病毒感染研究进展[J].现代实用医学，2020，32（5）：468-470，526.
[7] Sandoni M，Ciardo L，Tamburini C，et al. Enteroviral Infections in the First Three Months of Life [J]. Pathogens，2022， 11（1）：60.
[8] Khetsuriani N，Lamonte A，Oberste MS，et al. Neonatal enterovirus infections reported to the national enterovirus surveillance system in the United States，1983-2003 [J]. Pediatr Infect Dis J，2006，25（10）：889-893.
[9] Lv XQ，Qian LH，Wu T，et al. Enterovirus infection in febrile neonates：A hospital-based prospective cohort study [J]. J Paediatr Child Health，2016，52（8）：837-841.
[10] Zhao X，Zhang G，Liu S，et al. Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B [J]. Cell，2019，177（6）：1553-1565.e16.
[11] Chen X，Qu X，Liu C，et al. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18 [J]. mBio，2022，13（4）：e0116622.
[12] Zhang M，Wang H，Tang J，et al. Clinical characteristics of severe neonatal enterovirus infection：a systematic review [J]. BMC Pediatr，2021，21（1）：127.
[13] 陆佩，张澜，程国强，等.新生儿肠道病毒感染81例回顾分析及不良结局评分系统的建立[J].中华新生儿科杂志，2019，（3）：177-181.
[14] Chen BS，Lee HC，Lee KM，et al. Enterovirus and Encephalitis [J]. Front Microbiol，2020，11：261.
[15] Majer A，McGreevy A，Booth TF. Molecular Pathogenicity of Enteroviruses Causing Neurological Disease [J]. Front Microbiol，2020，11：540.
[16] Li D，Sun T，Tao L，et al. A mouse-adapted CVA6 strain exhibits neurotropism and triggers systemic manifestations in a novel murine model [J]. Emerg Microbes Infect，2022， 11（1）：2248-2263.
[17] 董源敏，陆楠，张彩.EV71病毒固有免疫逃逸机制的研究进展[J].中华微生物学和免疫学杂志，2021，41（6）：493-500.
[18] Voss M，Pinkert S，Kespohl M，et al. A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulence [J]. Viruses，2022，14（4）：769.
[19] Xing J，Wang K，Wang G，et al. Recent advances in enterovirus A71 pathogenesis：a focus on fatal human enterovirus A71 infection [J]. Arch Virol，2022，167（12）：2483- 2501.
[20] Baggen J，Thibaut HJ，Strating J，et al. The life cycle of non-polio enteroviruses and how to target it [J]. Nat Rev Microbiol，2018，16（6）：368-381.
[21] Nikolaidis M，Mimouli K，Kyriakopoulou Z，et al. Large- scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses [J]. Virology，2019，526：72-80.
[22] Moliner-Calderon E，Rabella-Garcia N，Turon-Vinas E，et al. Relevance of enteroviruses in neonatal meningitis [J]. Enferm Infecc Microbiol Clin （Engl Ed），2023. DOI：10.1016/ j.eimce.2022.12.012.
[23] 吴运芹，高喜容，詹敏，等.新生儿肠道病毒感染86例临床分析[J].中国小儿急救医学，2020，27（12）：925-928.
[24] 封志纯，张华岩，韩树萍，等.新生儿肠道病毒感染诊疗与预防专家共识[J].临床儿科杂志，2021，39（3）：161- 166.
[25] Chen YC，Yang SL，Yang H，et al. Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization [J]. J Microbiol Immunol Infect，2021，54（4）：581-587.
[26] Verboon-Maciolek MA，Groenendaal F，Cowan F，et al. White matter damage in neonatal enterovirus meningoencephalitis [J]. Neurology，2006，66（8）：1267-1269.
[27] Wu T，Fan XP，Wang WY，et al. Enterovirus infections are associated with white matter damage in neonates [J]. J Paediatr Child Health，2014，50（10）：817-822.
[28] 石晶.新生儿肠道病毒感染临床诊断治疗[J].中华实用儿科临床杂志，2021，36（14）：1049-1051.
[29] Olchawa-Czech A，Ptak K，Szymonska I，et al. Severe enterovirus infections in infants <3 months of age and the importance of medical history [J]. J Mother Child，2021，24（3）：37-44.
[30] Toczylowski K，Wojtkowska M，Sulik A. Enteroviral meningitis reduces CSF concentration of Aβ42，but does not affect markers of parenchymal damage [J]. Eur J Clin Microbiol Infect Dis，2019，38（8）：1443-1447.
[31] Wei X，Yang J，Gao L，et al. The transfer and decay of maternal antibodies against enterovirus A71，and dynamics of antibodies due to later natural infections in Chinese infants：a longitudinal，paired mother-neonate cohort study [J]. Lancet Infect Dis，2021，21（3）：418-426.
[32] Guan X，Che Y，Wei S，et al. Effectiveness and Safety of an Inactivated Enterovirus 71 Vaccine in Children Aged 6-71 Months in a Phase Ⅳ Study [J]. Clin Infect Dis，2020，71（9）：2421-2427.
[33] Xu N，Yang J，Zheng B，et al. The Pyrimidine Analog FNC Potently Inhibits the Replication of Multiple Enteroviruses [J]. J Virol，2020，94（9）：e00204-20.
[34] Wang K，Zheng B，Zhang L，et al. Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B [J]. Nat Commun，2020，11（1）：4419.
京公网安备 11010502046598号