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老年脓毒症患者血清SDC-1、CitH3水平表达及临床意义
李聪1  李丽丽1  刘辉2
1. 辽宁省健康产业集团抚矿总医院急诊科,辽宁抚顺   113008;
2.辽宁省健康产业集团抚矿总医院麻醉科,辽宁抚顺   113008
Expression and clinical significance of serum SDC-1 and CitH3 levels in elderly patients with sepsis
LI Cong1   LI Lili1   LIU Hui2
1.Department of Emergency, Fukuang General Hospital of Liaoning Health Industry Group, Liaoning Province, Fushun   113008, China; 
2.Department of Anesthesiology, Fukuang General Hospital of Liaoning Health Industry Group, Liaoning Province, Fushun   113008, China
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摘要 目的 探讨老年脓毒症患者血清多配体蛋白聚糖-1(SDC-1)、瓜氨酸组蛋白H3(CitH3)水平表达及临床意义。 方法 选取2017年8月至2022年9月辽宁省健康产业集团抚矿总医院(以下简称“我院”)收治的125例老年脓毒症患者为脓毒症组,根据病情严重程度分为普通脓毒症组51例和脓毒性休克组74例,根据28 d预后分为死亡组和存活组,另选取我院同期50名体检健康者为对照组。检测血清SDC-1、CitH3水平;通过多因素logistic回归分析老年脓毒症患者预后不良的影响因素,受试者操作特征(ROC)曲线分析血清SDC-1、CitH3对老年脓毒症患者预后不良的预测价值。 结果 脓毒症组血清SDC-1、CitH3水平高于对照组(P<0.05)。脓毒性休克组血清SDC-1、CitH3水平高于普通脓毒症组(P<0.05)。死亡组血清SDC-1、CitH3水平高于存活组(P<0.05)。年龄增加、脓毒性休克、合并器官损伤≥3个、抗感染启动时间延长、脓毒症相关性器官功能衰竭评价(SOFA)增加、SDC-1升高、CitH3升高为老年脓毒症患者预后不良的独立危险因素(P<0.05)。ROC曲线分析显示,SDC-1联合CitH3预测老年脓毒症患者预后不良的曲线下面积大于SDC-1、CitH3单独预测(P<0.05),SOFA评分与SDC-1联合CitH3预测老年脓毒症患者预后不良的曲线下面积比较,差异无统计学意义(P>0.05)。 结论 老年脓毒症患者血清SDC-1、CitH3水平升高,二者联合检测可作为老年脓毒症患者预后不良的预测指标。

 

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李聪1  李丽丽1  刘辉2
关键词 老年脓毒症多配体蛋白聚糖-1瓜氨酸组蛋白H3预后
    
Abstract:Objective To investigate the expression and clinical significance of serum syndecan-1 (SDC-1) and citrullinated histone H3 (CitH3) in elderly patients with sepsis. Methods A total of 125 elderly patients with sepsis admitted to Fukuang General Hospital of Liaoning Health Industry Group (“our hospital” for short) from August 2017 to September 2022 were selected as the sepsis group. According to the severity of the condition, they were divided into general sepsis group (51 cases) and septic shock group (74 cases). According to the 28 day prognosis, they were divided into death group and survival group. In addition, 50 healthy individuals who underwent physical examination in our hospital during the same period were selected as the control group. The serum levels of SDC-1 and CitH3 were measured; multivariate logistic regression was used to analyze the influencing factors of poor prognosis in elderly patients with sepsis, and receiver operating characteristic curve (ROC) curve analysis was used to analyze the predictive value of serum SDC-1 and CitH3 for poor prognosis in elderly patients with sepsis. Results The levels of serum SDC-1 and CitH3 in the sepsis group were higher than those in the control group (P<0.05). The levels of serum SDC-1 and CitH3 in septic shock group were higher than those in general sepsis group (P<0.05). The levels of serum SDC-1 and CitH3 in the death group were higher than those in the survival group (P<0.05). Increasing age, septic shock, organ injuries≥3 concurrent, prolonged anti infection initiation time, increased sepsis-related organ failure assessment scores, elevated SDC-1, and elevated CitH3 were independent risk factors for poor prognosis in elderly patients with sepsis (P<0.05). The ROC curve analysis showed that the area under the curve of SDC-1 combined with CitH3 in predicting poor prognosis in elderly sepsis patients was larger than that of SDC-1 and CitH3 alone (P<0.05). There was no difference between the SOFA score and the area under the curve of SDC-1 combined with CitH3 in predicting poor prognosis in elderly sepsis patients (P>0.05). Conclusion The levels of serum SDC-1 and CitH3 in elderly patients with sepsis are elevated, and the combined detection of the two can be used as predictor of poor prognosis in elderly patients with sepsis.
Key wordsElderly    Sepsis    Syndecan-1    Citrullinated histone H3    Prognosis
    
基金资助:辽宁省卫生健康委员会科研课题(201901077)。
引用本文:   
李聪1  李丽丽1  刘辉2. 老年脓毒症患者血清SDC-1、CitH3水平表达及临床意义[J]. 中国医药导报, 2023, 20(22): 92-96.
LI Cong1 LI Lili1 LIU Hui2. Expression and clinical significance of serum SDC-1 and CitH3 levels in elderly patients with sepsis. 中国医药导报, 2023, 20(22): 92-96.
链接本文:  
https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.22.20     或     https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I22/92

 

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