Correlation analysis of pulmonary function indicators and inflammatory indicators in patients with acute exacerbation of chronic obstructive pulmonary disease
CAO Haiyan1 CHEN Long2 CHU Xiangjian3
1.Department of Respiratory and Critical Care, Rugao People’s Hospital, Jiangsu Province, Rugao 226500, China;
2.Department of Respiratory Medicine, Rugao People’s Hospital, Jiangsu Province, Rugao 226500, China;
3.Department of Radiotherapy, Rugao People’s Hospital, Jiangsu Province, Rugao 226500, China
Abstract：Objective To explore the correlation between pulmonary function indicators and inflammatory indicators in patients with chronic obstructive pulmonary disease. Methods From March to August 2022, 68 patients with chronic obstructive pulmonary disease admitted to the Department of Respiratory Medicine, Rugao People’s Hospital, Jiangsu Province were selected. They were divided into stable group (31 cases) and acute exacerbation group (37 cases) according to the disease status. Serum interleukin-33 (IL-33), C-reactive protein (CRP), tumor necrosis factor (TNF-α）, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in one second/forced vital capacity (FEV1/FVC) between two groups were compared; the correlation of lung function indicators and inflammatory factors indicators were analyzed. Results FVC, PEF, and FEV1/FVC in acute exacerbation group were lower than those in stable group, IL-33, CRP, TNF-α, NLR, PLR, and RDW were higher than those in stable group (P＜0.05). In acute exacerbation patients, FVC was negatively correlated with IL-33, CRP, and PLR; PEF was negatively correlated with IL-33 and TNF-α, NLR, and PLR; FEV1/FVC was negatively correlated with IL-33 and TNF-α, NLR, and RDW (r＜0, P＜0.05). Conclusion Factors such as CRP, NLR, PLR, and RDW are correlated with pulmonary function indicators of patients with chronic obstructive pulmonary disease, which can be used to assist in assessing the disease changes in patients with chronic obstructive pulmonary disease.
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