Abstract：Objective To analyze the risk factors for early neurological deterioration (END) in patients with isolated subcortical infarction. Methods A total of 422 patients who were hospitalized in the Department of Neurology of Cangzhou Central Hospital from January 2021 to March 2022 and diagnosed as isolated subcortical infarction by MRI were selected as the research objects. National Institutes of Health stroke scale (NIHSS) score was used to assess the degree of neurological impairment of all patients on the day of admission and within three days after admission. If the NIHSS score increased ≥2 points within 72 hours after admission, it was considered that END had occurred. Then, patients were divided into the END group (81 cases) and the non-END group (341 cases) according to whether END occurred. Baseline data and risk factors of the two groups were compared, and the independent risk factors for predicting END were screened out. Results There were significant differences in age, male ratio, stroke history, lesion diameter, and carrier artery stenosis between the two groups （P＜0.05）. Logistic regression analysis showed that male (OR=3.084, 95%CI:1.500-6.340, P=0.002), stroke history (OR=2.391, 95%CI:1.158-4.937, P=0.018), lesion diameter ＞2 cm (OR=3.038, 95%CI:1.434-6.436, P=0.004) and carrier artery stenosis (OR=14.157, 95%CI: 7.602-26.363, P＜0.001) were independent risk factors for END in patients with acute isolated subcortical infarction. Conclusion Isolated subcortical infarction patients with male, stroke history, lesion diameter＞2.0 cm, and carrier artery stenosis are more likely to develop END, which should arouse clinical attention.
李倩 曲明卫 王宁宁 王立敏 范桂梅 杨潮萍. 孤立性皮质下梗死患者早期神经功能恶化的危险因素分析[J]. 中国医药导报, 2023, 20(20): 109-112.
LI Qian QU Mingwei WANG Ningning WANG Limin FAN Guimei YANG Chaoping. Analysis of risk factors for early neurological deterioration in patients with isolated subcortical infarction. 中国医药导报, 2023, 20(20): 109-112.
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