Mining medication law of traditional Chinese medicine treatment of osteoporotic fracture under the guidance of three-stage syndrome differentiation based on traditional Chinese medicine inheritance support system
DU Mengfan1 CHEN Can1 CHEN Yiren1 GUO Shuang1 ZHAO Yu1 ZHANG Yan2 LIU Junning2 NIU Susheng2
1.College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fujian Province, Fuzhou 350122, China;
2.Key Laboratory of Orthopedics & Traumatology and Rehabilitation of Traditional Chinese Medicine, Ministry of Education, Fujian University of Traditional Chinese Medicine, Fujian Province, Fuzhou 350122, China
Abstract：Objective To explore the medication rule of traditional Chinese medicine for osteoporotic fracture under the theory of three-stage syndrome differentiation, and to provide reference for clinical treatment of osteoporotic fracture. Methods Through CNKI, Wanfang Data, and VIP, literatures related to the use of traditional Chinese medicine prescriptions in the treatment of osteoporotic fractures from inception to May 2022 was collected, prescription data were screened and sorted out, and standardized processing was carried out. The traditional Chinese medicine inheritance support system system (V 2.5) was used to conduct drug classification, normalization of nature and flavour, formula composition rule, and entropy cluster analysis. Results After retrieval and removal, 2 009 articles were included, including 100 prescriptions in the early stage, 95 in the middle stage, and 95 in the late stage. In the early stage of osteoporotic fracture, the most frequently used drug was Fos Carthami, and the most frequently used drugs were Radix Angelicae Sinensis and Cortex Eucommiae in the middle and late stage. In three-stage, the four nature of drugs were mainly warm, cold, clam, and the five flavour of drugs were mainly sweet, bitter, and pungent. Liver, kidney, spleen, and heart channels with high frequency of meridian conversion were developed, and six common drug pairs and three new prescriptions were obtained. Conclusion Clinical treatment of osteoporotic fracture can be based on the three-stage syndrome differentiation, flexible use the drugs of promoting blood circulation for removing blood stasis, relieving pain and harmonizing ying, nourishing liver and kidney, replenishing qi and blood, improve the effect of Chinese medicine treatment.
杜梦凡1 陈灿1 陈一仁1 郭双1 赵宇1 张燕2 刘俊宁2 牛素生2. 基于中医传承辅助系统挖掘三期辨证指导下中医治疗骨质疏松性骨折的用药规律[J]. 中国医药导报, 2023, 20(20): 34-38.
DU Mengfan1 CHEN Can1 CHEN Yiren1 GUO Shuang1 ZHAO Yu1 ZHANG Yan2 LIU Junning2 NIU Susheng2. Mining medication law of traditional Chinese medicine treatment of osteoporotic fracture under the guidance of three-stage syndrome differentiation based on traditional Chinese medicine inheritance support system. 中国医药导报, 2023, 20(20): 34-38.
京公网安备 11010502046598号