Abstract：Objective To explore the effect of Metformin on glycolipid metabolism and homocysteine levels in patients with schizophrenia treated with Risperidone. Methods A total of 102 schizophrenic patients treated with Risperidone in Fuyang Third People’s Hospital, Anhui Province from July 2021 to July 2022 were selected and divided into control group and study group by random number table method, with 51 cases in each group. On the basis of maintaining Risperidone treatment, the control group was given placebo and the study group was given Metformin. Both groups were treated for three months. The clinical efficacy, waist-to-hip ratio, glucose, and lipid metabolism indexes (fasting blood glucose [FPG], 2 h postmeal blood glucose [2hPG], fasting insulin [FINS], total cholesterol [TC]), and homocysteine (Hcy) levels were compared between the two groups before and after treatment. The occurrence of adverse reactions during treatment was recorded in both groups. Results There was no significant difference in clinical efficacy between the two groups (P＞0.05). After treatment, the levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the study group were not significantly different from those before treatment (P＞0.05), while the levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the control group were higher than those before treatment (P＜0.05). The levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the study group were lower than those in the control group (P＜0.05). After treatment, the Hcy level in both groups was lower than before treatment, and the study group was lower than the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion In the treatment of schizophrenia with Risperidone, the addition of Metformin can prevent the increase of waist-to-hip ratio, abnormal glucose, and lipid metabolism, regulate the level of Hcy, and will not affect the therapeutic effect of Risperidone, and is safe and reliable.
闫真 吴延海 谭陈晨 孙龙龙 李叶新. 二甲双胍对利培酮治疗的精神分裂症患者糖脂代谢及同型半胱氨酸水平的影响[J]. 中国医药导报, 2023, 20(19): 117-120.
YAN Zhen WU Yanhai TAN Chenchen SUN Longlong LI Yexin. Effect of Metformin on glycolipid metabolism and homocysteine levels in patients with schizophrenia treated with Risperidone. 中国医药导报, 2023, 20(19): 117-120.
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