Clinicopathologic analysis of 27 cases of cellular angiofibroma
ZHANG Kang1 LI Xiangli2 JIANG Guoqing1
1.Department of Gynecology, the First Hospital of Tsinghua University, Beijing 100016, China;
2.Department of Pathology, the First Hospital of Tsinghua University, Beijing 100016, China
Abstract：Objective To investigate the clinical features, pathology, immunohistochemistry of cellular angiofibroma. Methods Clinical data of 26 cases reported in China from January 2000 to June 2022 in CNKI and Wanfang Data, and one case of cellular angiofibroma admitted to the First Hospital of Tsinghua University (hereinafter referred to as “our hospital”) on February 18, 2022 were collected. The characteristics of clinical, pathological, and immunohistochemical of the case were analyzed. Results The patient in our hospital was 44 years old, and was diagnosed with vulvar mass for three months, enlargement accompanied by tenderness for two weeks. The mass was located in the right medial lip of the minora, with a size of 9 cm. Pathologically, it showed short spindle cells with uniform distribution, more mitotic images, and large cell atypia. Small and medium blood vessels can be seen in the interstitium, and some blood vessels have thicker walls, accompanied by hyaline degeneration. Immunohistochemistry: CD34 (vessel +), Desimn (vessel +), Vimentin (+), SATA6 (-), S-100 (-), Ki-67 index (30%), SMA (vessel +), ER (+), PR (+). A total of 26 patients aged 16-78 years were reported, including 18 females and eight males. There were 21 cases with no pain and five cases with mild pain. The growth sites were the labia majora in 13 cases, the scrotum in four cases, the middle finger in two cases, the groin in two cases, the pubic mound in one case, the vulva in one case, the spermatocele in one case, the labia minora in one case, and the cervix in one case. The course of disease ranges from one week to ten years. The pathological features were composed of short spindle cells with the same morphology and abundant blood vessels. Immunohistochemistry showed that Vimentin was diffusion-positive, CD34, ER, PR, SMA were positive or partially positive, and Desimin, HMB45, S-100 were mostly negative. In the literatures, among the 26 patients who received surgical treatment, two patients were suspected to have relapsed, and one patient in our hospital did not have recurrence after surgery. Conclusion Cellular angiofibroma is a rare mesenchymal tumor, most common in the bisexual genital area. It is characterized by dense short spindle cells and abundant blood vessels under microscope. Surgical resection is the main treatment, and the patient has a good prognosis.
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