Influence and predictive value of serum 25-hydroxyvitamin D3 and chemokine on the occurrence of coronary artery lesion in children with Kawasaki disease
LI Nana WANG Hongqun▲
Department of Pediatrics, the Second People’s Hospital of Wuhu City, Anhui Province, Wuhu 241000, China
Abstract：Objective To analyze the influence and prognostic value of serum 25-hydroxyvitamin D3 [25(OH)D3] and chemokine on the occurrence of coronary artery lesion (CAL) in children with Kawasaki disease (KD). Methods A total of 86 KD children admitted to the Second People’s Hospital of Wuhu City, Anhui Province from July 2018 to November 2022 were selected as the study objects. After two weeks of treatment, the patients were divided into the occurrence group (21 cases) and the non-occurrence group (65 cases) according to the occurrence of CAL. The clinical data, serum levels of 25(OH)D3, and lipid-derived cytokines were compared between the two groups, and the influencing factors of the occurrence of CAL in KD children were analyzed, and the predictive value of the combined detection of serum 25(OH)D3 and lipid-derived cytokines on the occurrence of CAL in KD children was further analyzed. Results The proportion of KD in acute phase, the proportion of intravenous immunoglobulin (IVIg) resistance, and the levels of procalcitonin, omentin-1, and chemokine before treatment in the occurrence group were higher than those in the non-occurrence group, the duration of fever before IVIg was longer than that in the non-occurrence group, and the serum 25(OH)D3 was lower than that in the non-occurrence group (P＜0.05). The results of multivariate logistic regression analysis showed that procalcitonin (OR= 2.759, 95%CI: 1.053-4.185), serum 25(OH)D3 (OR=0.310, 95%CI: 0.128-0.754), and chemokine (OR=3.364, 95%CI: 2.063-7.125) were the influencing factors of CAL occurrence in KD children (P＜0.05). The analysis of the receiver operation characteristic curve showed that the area under the curve of serum 25(OH)D3 combined with chemokine predicted CAL development in KD children was higher than those predicted by the two alone (P＜0.05). Conclusion Procalcitonin, serum 25(OH)D3, and chemokine are all related factors affecting the occurrence of CAL in KD children, and the combination of serum 25(OH)D3 and chemokine has a higher predictive effect on the occurrence of CAL in KD children.
李娜娜 王红群▲. 血清25-羟维生素D3、趋化因子对川崎病患儿冠状动脉损害发生的影响及预测价值[J]. 中国医药导报, 2023, 20(19): 104-107.
LI Nana WANG Hongqun▲. Influence and predictive value of serum 25-hydroxyvitamin D3 and chemokine on the occurrence of coronary artery lesion in children with Kawasaki disease. 中国医药导报, 2023, 20(19): 104-107.
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