Abstract：Objective To explore the effect of resistance movement combined with nutrition intervention on senile patients with sarcopenia. Methods A total of 500 elderly patients with sarcopenia admitted to Shijiazhuang People’s Hospital from May 2016 to May 2021 were selected and divided into two groups with 250 patients each by simple random sampling method. The control group received conventional intervention combined with nutrition intervention, while based on the control group, the observation group was combined with resistance exercise. The levels and changes of body weight, grip strength, walking speed, and skeletal muscle density at each stage were compared between the two groups, as well as the relevant indexes of oxidative stress response before and after treatment. Results At six months after treatment, grip, pace, skeletal muscle density, and limb skeletal muscle mass in two groups were higher than before treatment, while those of observation group were higher than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in muscle mass index between the two groups (P＞0.05). At six months after treatment, the contents of homocysteine, interferon-γ, and malondialdehyde in both groups were lower than those before treatment, while those of the observation group were lower than those of the control group; the content of superoxide dismutase in the two groups was higher than that before treatment, while the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). Conclusion Resistance movement combined with nutritional intervention can effectively improve the level of grip, pace, skeletal muscle density, and other related indicators in elderly patients with sarcopenia, stabilize oxidative stress indicators, and thus improve prognosis and quality of life.
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