Abstract：Objective To investigate the relationship between plasma albumin (PA), free protein S (fPS), and D-dimer (D-D) and onset of preeclampsia (PE). Methods A total of 112 patients with PE who underwent regular obstetric examinations in Liyang People’s Hospital of Jangsu Province (“our hospital”for short) from January 2020 to December 2021 were selected as PE group, and 120 healthy pregnant women who underwent obstetric inspection in our hospital during the same period were selected as control group. The general data and clinical data, plasma PA, fPS, and D-D were compared between two groups; the influencing factors of onset of PE were analyzed by logistic regression analysis; the predictive value of plasma PA, fPS, and D-D to the onset of PE was determined by receiver operating characteristic curve. Results The levels of systolic blood pressure, diastolic blood pressure, urine protein, serum uric acid, fibrinogen, homocysteine, high-sensitivity C-reactive protein, and D-D in PE group were higher than those in control group; while activated partial thrombin time , plasma PA, and fPS were lower than those in control group (P＜0.05). Fibrinogen (OR=2.855), PA (OR=0.314), fPS (OR= 0.297), and D-D (OR=3.053) were the influencing factors of onset of PE (P＜0.05). The area under the curve of the combined detection of PA, fPS, and D-D was higher than that of the independent detection of each index. Conclusion Plasma PA, fPS, and D-D are related to the incidence of PE, and the combination detection of plasma PA, fPS, and D-D is of high diagnostic value for PE.
[1] Turbeville HR，Sasser JM. Preeclampsia beyond pregnancy：long-term consequences for mother and child [J]. Am J Physiol Renal Physiol，2020，318（6）：F1315-F1326.
[2] Stepan H，Hund M，Andraczek T. Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia：The Angiogenic-Placental Syndrome [J]. Hypertension，2020，75（4）：918-926.
[3] Nirupama R，Divyashree S，Janhavi P，et al. Preeclampsia：Pathophysiology and management [J]. J Gynecol Obstet Hum Reprod，2021，50（2）：975-978.
[4] 程敏，李青，李志芳.红细胞压积及白蛋白指标评估子痫前期治疗效果的应用价值研究[J].河北医药，2022，44（8）：1221-1223.
[5] 赵先兰，高丹丹，张文静.血浆游离蛋白S、蛋白C及抗凝血酶Ⅲ活性变化与子痫前期相关性研究[J].中国妇产科临床杂志，2020，21（4）：402-405.
[6] Tasic N，Paixao T，Goncalves LM. Biosensing of D-dimer，ma- king the transition from the central hospital laboratory to bedside determination [J]. Talanta，2020，207（36）：270-275.
[7] 谢幸，孔北华.妇产科学[M].9版.北京：人民卫生出版社，2018：83-84.
[8] Ives CW，Sinkey R，Rajapreyar I，et al. Preeclampsia-Pathophysiology and Clinical Presentations：JACC State-of-the- Art Review [J]. J Am Coll Cardiol，2020，76（14）：1690-1702.
[9] 温伦辉，温梅英，赖晓珺.妊娠晚期子痫前期发病与凝血指标及血小板参数的相关性[J].中国妇幼保健，2021，36（12）：2721-2723.
[10] Opichka MA，Rappelt MW，Gutterman DD，et al. Vascular Dysfunction in Preeclampsia [J]. Cells，2021，10（11）：46-51.
[11] Matsubara K，Matsubara Y，Uchikura Y，et al. Pathophysiology of Preeclampsia：The Role of Exosomes [J]. Int J Mol Sci，2021，22（5）：49-52.
[12] Jung E，Romero R，Yeo L，et al. The etiology of preeclampsia [J]. Am J Obstet Gynecol，2022，226（2）：S844-S866.
[13] 赵玉杰，吕艳关.纤维蛋白原与血清淀粉样蛋白A检测在子痫前期诊断中的价值[J].检验医学，2020，5（1）：79-80.
[14] 汪莲，陈先侠.白蛋白及血浆扩容治疗早发型子痫前期的临床疗效[J].蚌埠医学院学报，2022，47（3）：353-355.
[15] Gierula M，Ahnstrom J. Anticoagulant protein S-New insights on interactions and functions [J]. J Thromb Haemost，2020，18（11）：2801-2811.
[16] Musaogullari A，Chai YC. Redox Regulation by Protein S- Glutathionylation：From Molecular Mechanisms to Implications in Health and Disease [J]. Int J Mol Sci，2020，21（21）：57-61.
[17] Al-Khafaji RA，Schierbeck L. Deep Venous Thrombosis in a Patient with a Moderate Pretest Probability and a Negative D-Dimer Test：A Review of the Diagnostic Algorithms [J]. J Blood Med，2020，11（24）：173-184.
[18] 颜芸，方建红，韩艳艳，等.血浆D-二聚体与子痫前期-子痫严重程度的相关性分析[J].中国优生与遗传杂志，2021，29（9）：1285-1288.
[19] V?觃zquez-Arredondo JG，V?觃zquez-Rodriguez JG. Plasma colloid osmotic pressure in preeclampsia. Review of the Mexican literature 1997-2018 [J]. Cir Cir，2021，89（4）：547-552.
[20] 吴宏，余盛楠，段丽娜.子痫前期患者血清白蛋白、整合素β1水平及诊断疾病意义[J].中国计划生育学杂志，2021，29（11）：2432-2435.
[21] Wang Y，Yang W. Proteome-Scale Analysis of Protein S-Acylation Comes of Age [J]. J Proteome Res，2021，20（1）：14- 26.
[22] Majumder R，Nguyen T. Protein S：function，regulation，and clinical perspectives [J]. Curr Opin Hematol，2021，28（5）：339-344.
[23] Ye H，Wu J，Liang Z，et al. Protein S-Nitrosation：Biochemistry，Identification，Molecular Mechanisms，and Therapeutic Applications [J]. J Med Chem，2022，65（8）：5902-5925.
[24] 孙燕，王哲.25-羟基维生素D、胱抑素-C、D-二聚体水平与子痫前期及妊娠结局的关系研究[J].中国性科学，2020，29（10）：64-67.
[25] 刘丽丽，朱启英，李晶.BMI、炎症指标、D-二聚体水平与子痫前期的相关性[J].新疆医科大学学报，2021，44（7）：831-834.
[26] 吴丽霞，陈淑珠.D-二聚体与凝血指标在妊娠期高血压孕妇中的临床检验价值[J].中国当代医药，2021，28（29）：178-180.
京公网安备 11010502046598号