Effects of corn silk aqueous extract on glucose and lipid metabolism and liver and kidney function in newly diagnosed mild type 2 diabetic elderly patients
CHENG Yu1，2 YANG Wenqin1 CHAO Hong1 QI Lei1 ZHOU Zhongguang2 LIU Jicheng1，2 GUAN Hong1
1.School of Public Health, Qiqihar Medical University, Heilongjiang Province, Qiqihar 161006, China;
2.Postdoctoral Workstation, Research Institute of Medical and Pharmacy, Heilongjiang Province, Harbin 150000, China
Abstract：Objective To investigate the effect of corn silk aqueous extract on glucose and lipid metabolism, liver and kidney function in newly diagnosed mild type2 diabetes mellitus (T2DM) elderly patients. Methods A total of 72 newly diagnosed mild T2DM elderly patients were recruited from the Second Affiliated Hospital of Qiqihar Medical College from June to October 2020, and they were divided into intervention group and control group by random number table method, with 36 cases in each group. The patients in the intervention group took 4.8 g corn silk aqueous extract every day, and the control group was given the same amount of toast powder as placebo. The indexes of glucose and lipid metabolism, liver, and kidney function were compared between the two groups. Results After treatment, fasting insulin, insulin resistance index, alanine aminotransferase, and aspartate aminotransferase in the intervention group were lower than before treatment, insulin sensitivity index, and total bilirubin were higher than before treatment, fasting blood glucose in the control group was higher than before treatment, and fasting blood glucose, fasting insulin, insulin resistance index, total cholesterol, aspartate aminotransferase and total bilirubin in the intervention group were lower than before treatment, insulin sensitivity index was higher than control group, the differences were statistically significant (P＜0.05). Conclusion The intervention of corn silk aqueous extract can improve fasting blood glucose and insulin resistance, regulate blood lipid, have no adverse effect on liver and kidney function in elderly patients with newly diagnosed mild T2DM.
[1] World Health Organization. Global report on diabetes[R].2016.
[2] Wang L，Gao P，Zhang M，et al. Prevalence and ethnic pattern of diabetes and prediabetes in China [J]. JAMA，2017，317（24）：2515-2523.
[3] Jing G，Meilin H，Zhaoyi H，et al. Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats [J]. Front Pharmacol，2017，8（3）：42.
[4] Hwang YC，Oh DH，Choi MC，et al. Compound K attenuates glucose intolerance and hepatic steatosis through AMPK -dependent pathways in type 2 diabetic OLETF rats [J]. Korean J Intern Med，2018，33（2）：347-355.
[5] Hatano A，Kanno Y，Kondo Y，et al. Synthesis and characterization of novel，conjugated，fluorescent DNJ derivatives for α-glucosidase recognition [J]. Bioorg Med Chem，2017， 25（2）：773-778.
[6] Xu J，Lian F，Zhao L，et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula [J]. ISME J，2015，9（3）：552-562.
[7] Li YB，Zhang WH，Liu H，et al. Protective effects of Huanglian Wendan decoction against cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus [J]. Chin J Nat Med，2016，14（11）：813-822.
[8] 张国丽，胡爱华，敖晓琳.玉米须提取物功能研究进展[J].农产品加工，2020（4）：93-95.
[9] 中国2型糖尿病防治指南（2017年版）[J].中华糖尿病杂志，2018，10（1）：4-67.
[10] 国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2015.
[11] 赵宵丹，丛丽.降糖药物对T2DM患者心衰风险影响研究的进展[J].心血管康复医学杂志，2021，30（4）：502-505.
[12] Guo J，Liu T，Han L，et al. The effects of corn silk on glyc- emic metabolism [J]. Nutr Metab （Lond），2009（6）：47-51.
[13] Wang KJ，Zhao JL. Corn silk （Zea mays L.），a source of nat- ural antioxidants with α-amylase，α-glucosidase，advanced glycation and diabetic nephropathy inhibitory activities [J]. Biomed Pharmacother，2019，110：510-517.
[14] Ho TY，Li CC，Lo HY，et al. Corn Silk Extract and Its Bioactive Peptide Ameliorated Lipopolysaccharide-Induced Inflammation in Mice via the Nuclear Factor-κB Signaling Pathway [J]. J Agric Food Chem，2017，65（4）：759-768.
[15] Sla?鬍ana■ Marijana J，Zorica B，et al. Antioxidant activity，phenolic profile，chlorophyll and mineral matter content of corn silk （Zea mays L）： Comparison with medicinal herbs [J]. J Cereal Sci，2016，69：363-370.
[16] Wen X，Yue L. The Influence of Corn Silk Polysaccharide on Signal Pathway of TGF-beta1 in Type 2 Diabetic Mellitus Rat [J]. Open Biomed Eng J，2015，9：204-208.
[17] Farsi DA，Harris CS，Reid L，et al. Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize （Zea mays） [J]. Phytother Res，2008，22：108-112.
[18] 寇义华，卢军利，董艳，等.玉米须煎剂对36例急性乙型黄疸型肝炎肝功能保护作用的临床研究[J].河北中医，2009，31（10）：1476-1477.
[19] Creeden JF，Gordon DM，Stec DE，et al. Bilirubin as a metabolic hormone： the physiological relevance of low levels [J]. Am J Physiol Endocrinol Metab，2021，320（2）：E191- E207.
[20] Du L，Ma X，Shen X，et al. Neonatal hyperbilirubinemia management：Clinical assessment of bilirubin production [J]. Semin Perinatol，2021，45（1）：151351.
[21] 王静.血清胆红素水平与2型糖尿病及其并发症发生的关联研究[J].湖北：华中科技大学，2016.
[22] 葛俐娜.血清胆红素、C反应蛋白、载脂蛋白A1在糖尿病足患者中的表达及诊断价值[J].中国当代医药，2022， 29（32）：58-61.
[23] 杜文晋，邢华冰，白秀平.2型糖尿病合并代谢相关脂肪性肝病患者血清总胆汁酸水平变化及其相关因素研究[J].中国医药，2022，17（11）：1657-1661.
[24] Cho MK，Kim MY. Self-Management Nursing Intervention for Controlling Glucose among Diabetes： A Systematic Review and Meta-Analysis [J]. Int J Environ Res Public Health，2021，8（23）：12750.
[25] Yang M，Ni C，Chang B，et al. Association between serum total bilirubin levels and the risk of type 2 diabetes mellitus [J]. Diabetes Res Clin Pract，2019，152：23-28.
[26] Abbasi A，Deetman PE，Corpeleijn E，et al. Bilirubin as a potential causal factor in type 2 diabetes risk：a Mendelian randomization study [J]. Diabetes，2015，64：1459-1469.
[27] Liu J，Dong H，Zhang Y，et al. Bilirubin increases insulin sensitivity by regulating cholesterol metabolism，adipokines and PPARgamma levels [J]. Sci Rep，2015，5：9886.
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